ArticleCurrent biology : CB2015
Light evokes rapid circadian network oscillator desynchrony followed by gradual phase retuning of synchrony.
Article in Current biology : CB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
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- The Neuropeptide PDF Is Crucial for Delaying the Phase ofJournal of biological rhythms · 2021Article
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- Weekend Light Shifts Evoke PersistentThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Integration of Circadian Clock Information in theJournal of biological rhythms · 2021Review
- Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS.Current biology : CB · 2021Article
- Peripheral Sensory Organs Contribute to Temperature Synchronization of the Circadian Clock inFrontiers in physiology · 2021Review
- Single-cell resolution long-term luciferase imaging in cultivatedmicroPublication biology · 2020Article
- Review
- Circadian disruption: What do we actually mean?The European journal of neuroscience · 2020Review
- The importance of determining circadian parameters in pharmacological studies.British journal of pharmacology · 2019Review
- Evidence for Internal Desynchrony Caused by Circadian Clock Resetting.The Yale journal of biology and medicine · 2019Review
- Neural Network Interactions Modulate CRY-Dependent Photoresponses inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior.Cold Spring Harbor perspectives in biology · 2018Review
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7 authors at 3 institutions in 1 country.
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Abstract
Circadian neural circuits generate near 24-hr physiological rhythms that can be entrained by light to coordinate animal physiology with daily solar cycles. To examine how a circadian circuit reorganizes its activity in response to light, we imaged period (per) clock gene cycling for up to 6 days at single-neuron resolution in whole-brain explant cultures prepared from per-luciferase transgenic flies. We compared cultures subjected to a phase-advancing light pulse (LP) to cultures maintained in darkness (DD). In DD, individual neuronal oscillators in all circadian subgroups are initially well synchronized but then show monotonic decrease in oscillator rhythm amplitude and synchrony with time. The small ventral lateral neurons (s-LNvs) and dorsal lateral neurons (LNds) exhibit this decrease at a slower relative rate. In contrast, the LP evokes a rapid loss of oscillator synchrony between and within most circadian neuronal subgroups, followed by gradual phase retuning of whole-circuit oscillator synchrony. The LNds maintain high rhythmic amplitude and synchrony following the LP along with the most rapid coherent phase advance. Immunocytochemical analysis of PER shows that these dynamics in DD and LP are recapitulated in vivo. Anatomically distinct circadian neuronal subgroups vary in their response to the LP, showing differences in the degree and kinetics of their loss, recovery and/or strengthening of synchrony, and rhythmicity. Transient desynchrony appears to be an integral feature of light response of the Drosophila multicellular circadian clock. Individual oscillators in different neuronal subgroups of the circadian circuit show distinct kinetic signatures of light response and phase retuning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.