ArticleMagnetic resonance in medicine2016
Separation of cellular and BOLD contributions to T2* signal relaxation.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 88 citations in OpenAlex.
- Brain oxygen extraction fraction mapping in patients with multiple sclerosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Trial
- A Generalized Approach to Solving Deep Learning-Based Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level Dependent Magnitude (QSM + qBOLD or QQ) for Oxygen Extraction Fraction (OEF) Mapping Across Diverse Acquisition Schemes.Magnetic resonance in medicine · 2026Article
- TE-aware state analysis and evolution in dynamic network connectivity.bioRxiv : the preprint server for biology · 2026Article
- AI-Powered Gradient Echo Plural Contrast Imaging (AI-GEPCI)-A Comprehensive Neurological Protocol From a Single MRI Scan.Journal of magnetic resonance imaging : JMRI · 2026Article
- Focused ultrasound blood-brain barrier opening reveals a paradoxical remote metabolic response in the primate brain.Science advances · 2026Article
- Reproducibility of QQ (QSM + qBOLD) Oxygen Extraction Fraction (OEF) Mapping in the Brain at 3 and 1.5 T.Magnetic resonance in medicine · 2026Article
- AI-powered Gradient Echo Plural Contrast Imaging (AI-GEPCI) - a Comprehensive Multiparametric Neurological Protocol from a Single MRI Scan.medRxiv : the preprint server for health sciences · 2026Article
- Evaluation of Hemodynamic and Blood Oxygen Metabolism Alterations in Parkinson's Disease Using Quantitative MRI.Current neuropharmacology · 2026Article
- Oxygen extraction fraction is differentially associated with pathological biomarkers in Alzheimer's disease and non-Alzheimer's dementias.Frontiers in neuroscience · 2026Article
- Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI.Experimental physiology · 2025Review
- Unraveling the major role of vascular (R2') contributions to R2* signal relaxation at ultra-high-field MRI: A comprehensive analysis with quantitative gradient recalled echo in mouse brain.Magnetic resonance in medicine · 2025Article
- Microstructural abnormalities in multiple system atrophy as revealed by conventional and rotating frame relaxation MRI parameters.Scientific reports · 2025Article
- Oxygen extraction fraction in small vessel disease: relationship to disease burden and progression.Brain : a journal of neurology · 2025Article
- In Vivo Characterization of Magnetic Inclusions in the Subcortex From Nonexponential Transverse Relaxation Decay.NMR in biomedicine · 2025Article
- CoRRECT: A Deep Unfolding Framework for Motion-Corrected Quantitative R2* Mapping.Journal of mathematical imaging and vision · 2025Article
- Increased periventricular thalamic damage gradient in multiple sclerosis detected by quantitative gradient echo MRI.Multiple sclerosis and related disorders · 2024Article
- Quantitative gradient recalled echo (qGRE) MRI enables in vivo measurement of pre-atrophic neurodegeneration in a mouse model of Alzheimer's disease.NeuroImage · 2024Article
- Multi-Echo Complex Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level-Dependent Magnitude (mcQSM + qBOLD or mcQQ) for Oxygen Extraction Fraction (OEF) Mapping.Bioengineering (Basel, Switzerland) · 2024Article
- Breath-hold calibrated fMRI mapping of absolute cerebral metabolic rate of oxygen metabolism (CMROImaging neuroscience (Cambridge, Mass.) · 2024Article
- Cerebral oxygen metabolism from MRI susceptibility.NeuroImage · 2023Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe development of a reliable clinical technique for quantitative measurements of the parameters defining the BOLD effect, i.e., oxygen extraction fraction (OEF), and deoxygenated cerebral blood volume, dCBV, is needed to study brain function in health and disease. Herein we propose such a technique that is based on a widely available gradient recalled echo (GRE) MRI. THEORY AND
methodsOur method is based on GRE with multiple echoes and a model of signal decay (Yablonskiy, MRM 1998) that takes into account microscopic cellular (R2), mesoscopic (BOLD), and macroscopic (background field gradients) contributions to the GRE signal decay with additional accounting for physiologic fluctuations.
resultsUsing 3 Tesla MRI, we generate high resolution quantitative maps of R2*, R2, R2', and tissue concentration of deoxyhemoglobin, the latter providing a quantitative version of SWI. Our results for OEF and dCBV in gray matter are in a reasonable agreement with the literature data.
conclusionThe proposed approach allows generating high resolution maps of hemodynamic parameters using clinical MRI. The technique can be applied to study such tissues as gray matter, tumors, etc.; however, it requires further development for use in tissues where extra- and intracellular compartments possess substantially different frequencies and relaxation properties (e.g., white matter).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.