ArticleInfection and immunity2015
Hfq plays important roles in virulence and stress adaptation in Cronobacter sakazakii ATCC 29544.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Insights into the genomic features of the emerging pathogens Cronobacter malonaticus and Cronobacter turicensis.Folia microbiologica · 2026Article
- DecipheringMicroorganisms · 2026Review
- Hemolysin III drives neuroinvasion and meningitis while impacting desiccation resilience inApplied and environmental microbiology · 2025Article
- NlpD as a crucial factor in desiccation resistance and biofilm formation in Cronobacter sakazakii.Scientific reports · 2025Article
- Considerations for oral and dental tissues in holistic care during long-haul space flights.Frontiers in physiology · 2024Review
- The RNA chaperone Hfq has a multifaceted role inFrontiers in cellular and infection microbiology · 2024Article
- Comprehensive Genomic Characterization ofMicroorganisms · 2023Article
- Uncovering virulence factors inApplied and environmental microbiology · 2023Article
- Role of Hfq in glucose utilization, biofilm formation and quorum sensing system in Bacillus subtilis.Biotechnology letters · 2022Article
- Molecular mechanism of enhanced ethanol tolerance associated withFrontiers in bioengineering and biotechnology · 2022Article
- Outer Membrane Protein F Is Involved in Biofilm Formation, Virulence and Antibiotic Resistance inMicroorganisms · 2021Article
- The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis.NPJ microgravity · 2021Review
- Current and Future Perspectives on the Role of Probiotics, Prebiotics, and Synbiotics in Controlling PathogenicFrontiers in microbiology · 2021Review
- Genomic Landscape and Phenotypic Assessment ofFrontiers in microbiology · 2021Article
- Expression of stress regulator and virulence genes ofFood science and biotechnology · 2020Article
- Random Mutagenesis Applied to Reveal Factors Involved in Oxidative Tolerance and Biofilm Formation in FoodborneFrontiers in microbiology · 2019Article
- Expression ofFood science and biotechnology · 2018Article
- New virulence factor CSK29544_02616 as LpxA binding partner in Cronobacter sakazakii.Scientific reports · 2018Article
- The Glutaredoxin Gene,Frontiers in microbiology · 2018Article
- The Role of Ribonucleases and sRNAs in the Virulence of Foodborne Pathogens.Frontiers in microbiology · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cronobacter spp. are opportunistic pathogens that cause neonatal meningitis and sepsis with high mortality in neonates. Despite the peril associated with Cronobacter infection, the mechanisms of pathogenesis are still being unraveled. Hfq, which is known as an RNA chaperone, participates in the interaction with bacterial small RNAs (sRNAs) to regulate posttranscriptionally the expression of various genes. Recent studies have demonstrated that Hfq contributes to the pathogenesis of numerous species of bacteria, and its roles are varied between bacterial species. Here, we tried to elucidate the role of Hfq in C. sakazakii virulence. In the absence of hfq, C. sakazakii was highly attenuated in dissemination in vivo, showed defects in invasion (3-fold) into animal cells and survival (10(3)-fold) within host cells, and exhibited low resistance to hydrogen peroxide (10(2)-fold). Remarkably, the loss of hfq led to hypermotility on soft agar, which is contrary to what has been observed in other pathogenic bacteria. The hyperflagellated bacteria were likely to be attributable to the increased transcription of genes associated with flagellar biosynthesis in a strain lacking hfq. Together, these data strongly suggest that hfq plays important roles in the virulence of C. sakazakii by participating in the regulation of multiple genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.