Evidence map›Paper›PMID 25753979›Full record

Trial reportClinical oral investigations2015

Salivary enzyme activity in anorexic persons—a controlled clinical trial.

Elżbieta Paszynska, Nadine Schlueter, Agnieszka Slopien, Monika Dmitrzak-Weglarz, Marta Dyszkiewicz-Konwinska, Christian Hannig

Abstract readClinical TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Review
  6. Eating disorders and oral health: a scoping review.Journal of eating disorders · 2023
    Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Elżbieta PaszynskaDepartment of Biomaterials and Experimental Dentistry, Poznan University of Medical Sciences, Bukowska 70, 60-812, Poznan, Poland. ela@pa.pl.
Nadine SchlueterDepartment of Conservative and Preventive Dentistry, Dental Clinic, Justus Liebig University, Giessen, Germany.
Agnieszka SlopienDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Monika Dmitrzak-WeglarzPsychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Marta Dyszkiewicz-KonwinskaDepartment of Biomaterials and Experimental Dentistry, Poznan University of Medical Sciences, Bukowska 70, 60-812, Poznan, Poland.
Christian HannigClinic of Operative Dentistry and Pediatric Dentistry, Faculty of Medicine 'Carl Gustav Carus', TU Dresden, Dresden, Germany.
Poznan University of Medical Sciences · PLUniversity Hospital Carl Gustav Carus · DEUniversity of Giessen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPatients with anorexia nervosa are at high risk for general and oral diseases. However, not all anorexic patients suffer from them, irrespective of the severity of their eating disorder. It is often speculated that differences in the saliva are important; however, little is known about salivary parameters in anorexic patients. The aim of the clinical trial was to evaluate stimulated and resting salivary flow rate and the activity of the following enzymes in both types of saliva: amylase, aspartate amino transferase (AST), alanine amino transferase (ALT), collagenase, lysozyme, peroxidase, serine and acidic proteases, and trypsin in persons with anorexia nervosa (AN) and to compare them with those of healthy controls. MATERIALS AND

methodsSixty-six subjects participated (28 patients with anorexia nervosa, 38 matched healthy controls).

resultsRegarding flow rate, stimulated and unstimulated levels were significantly lower in the AN group than in the controls. Activities of collagenase and AST in stimulated saliva were significantly higher in anorexic participants. In the AN group, changes due to salivary stimulation were found for the activity of acidic proteases, AST, and lysozyme.

conclusionReduced salivary flow might be one indicator of anorexia. Despite starvation and anorexia development, salivary key enzymes show physiological activity. This indicates a partial adaptation of the organism to severe condition during malnutrition. CLINICAL RELEVANCE: Further research is needed into possible role of reduced collagenase and transaminase activities in maintaining protection against external noxae and bacteria which might have impact on general oral health among patients with anorexia nervosa.

Indexed as

AdolescentAnorexia NervosaChildFemaleHumansMaleSalivaAmylaseAnorexia nervosaEating disordersEnzymesLysozymePeroxidaseProteaseSaliva

Identifiers

PMID25753979
OpenAlexW2061396754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.