Trial reportClinical oral investigations2015
Streptococcus mutans and Streptococcus sobrinus colonization and caries experience in 3- and 5-year-old Thai children.
Trial report in Clinical oral investigations, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Biological Validation of the PSC-MCAT: Analyzing Dental Plaque Microbiota Across Caries Risk Levels in Preschoolers.International dental journal · 2026Article
- Metagenomic insights into microbial community alterations and co-occurrence networks in infective endocarditis.Genomics & informatics · 2025Article
- Regulation of NADPathogens (Basel, Switzerland) · 2025Article
- Effect of adiposity status on salivary Streptococcus mutans and Streptococcus sobrinus.Oral diseases · 2025Article
- The Infant Oral Microbiome: Developmental Dynamics, Modulating Factors, and Implications for Oral and Systemic Health.International journal of molecular sciences · 2025Review
- Antibacterial activity of microwave synthesized hydroxyapatite against cariogenic bacteria: A preliminary study.The Saudi dental journal · 2024Article
- Comparison of biofilm models for producing artificial active white spot lesions.Journal of applied oral science : revista FOB · 2024Article
- Arginine-induced metabolomic perturbation inJournal of oral microbiology · 2022Article
- Multimodal Data Integration Reveals Mode of Delivery and Snack Consumption Outrank Salivary Microbiome in Association With Caries Outcome in Thai Children.Frontiers in cellular and infection microbiology · 2022Article
- Genomic and phenotypic characterization ofFrontiers in microbiology · 2022Article
- Oral hygiene and oral microbiota in children and young people with neurological impairment and oropharyngeal dysphagia.Scientific reports · 2021Article
- [Association of sepM gene mutation with mutacin Ⅳ production byNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Impact of polyols on Oral microbiome of Estonian schoolchildren.BMC oral health · 2019Article
- AnActa biomaterialia odontologica Scandinavica · 2019Article
- Relationship between the genetic polymorphisms of vicR and vicK Streptococcus mutans genes and early childhood caries in two-year-old children.BMC oral health · 2018Article
- Article
- Functional profiles of coronal and dentin caries in children.Journal of oral microbiology · 2018Article
- Differences in carbon source usage by dental plaque in children with and without early childhood caries.International journal of oral science · 2017Article
- Improved method for rapid and accurate isolation and identification of Streptococcus mutans and Streptococcus sobrinus from human plaque samples.Journal of microbiological methods · 2017Article
- Correlation between dental caries experience and mutans streptococci counts by microbial and molecular (polymerase chain reaction) assay using saliva as microbial risk indicator.Dental research journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
objectivesThe aim of this study was to examine the colonization of Streptococcus mutans and Streptococcus sobrinus in supra-gingival plaque samples and to determine their correlation with the prevalence of early childhood caries (ECC) in Thai children. MATERIALS AND
methodsA total of 344 Thai children, ages 3 and 5 years, were invited to participate in this study. Caries status of the children was examined. Supra-gingival plaque samples were collected. Quantitative real-time PCR was performed to evaluate DNA levels of S. mutans and S. sobrinus.
resultsEighty-five percent of the children were colonized by S. mutans and 50.9% of them were colonized by S. sobrinus. The prevalence of ECC was 43.8% and 56.2% among 3- and 5-year-old children, respectively, and was significantly associated with the presence of S. mutans and S. sobrinus. The severity of ECC was significantly correlated with increased DNA levels of the two bacteria. Children who were positive for S. mutans and S. sobrinus (Sm+/Sb+) were 8 times or 44 times more likely to experience ECC than children who were Sm-/Sb + or were Sm-/Sb-.
conclusionsThe study evidence further suggest that children colonized by both S. mutans and S. sobrinus are at the higher risk for ECC. CLINICAL RELEVANCE: Molecular-based qPCR can be used to detect and quantify S. mutans and S. sobrinus colonization for epidemiological and clinical studies for ECC risk assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.