Evidence map›Paper›PMID 25753974›Full record

ArticleHypertension (Dallas, Tex. : 1979)2015

Association of sex hormones with carotid artery distensibility in men and postmenopausal women: multi-ethnic study of atherosclerosis.

Dhananjay Vaidya, Sherita H Golden, Nowreen Haq, Susan R Heckbert, Kiang Liu, Pamela Ouyang

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cardiovascular Complications of Androgen Deprivation Therapy for Prostate Cancer.Current treatment options in cardiovascular medicine · 2017
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dhananjay VaidyaFrom the Johns Hopkins University School of Medicine, Baltimore, MD (D.V., S.H.G., N.H., P.O.); Department of Epidemiology, University of Washington, Seattle (S.R.H.); and Northwestern University School of Medicine, Chicago, IL (K.L.). dvaidya1@jhmi.edu.
Sherita H GoldenFrom the Johns Hopkins University School of Medicine, Baltimore, MD (D.V., S.H.G., N.H., P.O.); Department of Epidemiology, University of Washington, Seattle (S.R.H.); and Northwestern University School of Medicine, Chicago, IL (K.L.).
Nowreen HaqFrom the Johns Hopkins University School of Medicine, Baltimore, MD (D.V., S.H.G., N.H., P.O.); Department of Epidemiology, University of Washington, Seattle (S.R.H.); and Northwestern University School of Medicine, Chicago, IL (K.L.).
Susan R HeckbertFrom the Johns Hopkins University School of Medicine, Baltimore, MD (D.V., S.H.G., N.H., P.O.); Department of Epidemiology, University of Washington, Seattle (S.R.H.); and Northwestern University School of Medicine, Chicago, IL (K.L.).
Kiang LiuFrom the Johns Hopkins University School of Medicine, Baltimore, MD (D.V., S.H.G., N.H., P.O.); Department of Epidemiology, University of Washington, Seattle (S.R.H.); and Northwestern University School of Medicine, Chicago, IL (K.L.).
Pamela OuyangFrom the Johns Hopkins University School of Medicine, Baltimore, MD (D.V., S.H.G., N.H., P.O.); Department of Epidemiology, University of Washington, Seattle (S.R.H.); and Northwestern University School of Medicine, Chicago, IL (K.L.).
University of Washington · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Genetic Determinants of Premature Vascular Dysfunction in FamiliesR01HL092165 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI VAIDYA, DHANANJAY MADHUKAR · 2009 to 2013
$2.7M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
Serum Sex Hormone Levels and Subclinical AtherosclerosisR01HL074338 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GAPSTUR, SUSAN M · 2003 to 2006
$1.1M
Serum Sex Hormonoe Levels &Subclinical AtherosclerosisR01HL074406 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI OUYANG, PAMELA · 2003 to 2006
$1.0M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1999 to 2001
$443k
NCATS NIH HHS UL1 TR 001079NCATS NIH HHS UL1 TR001079NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS R01 HL074338NHLBI NIH HHS R01 HL074406NHLBI NIH HHS R01 HL092165NHLBI NIH HHS R01 HL74338NHLBI NIH HHS R01 HL92165
6 · The paper itself

Abstract

The decline in carotid distensibility with age is steeper in women than in men, however, the correlates of this sex difference are not known. We examined the association of bioavailable testosterone, estradiol, dehydroepiandrosterone, and sex hormone-binding globulin, in 2783 postmenopausal women and 2987 men aged 45 to 84 years at the Multi-Ethnic Study of Atherosclerosis baseline examination. Carotid artery lumen diameters by ultrasound and brachial artery blood pressures were measured at systole and diastole. Regression models to determine the association of carotid distensibility coefficient and lumen diameter with sex-specific quartiles of sex hormones were adjusted for age, race, height, weight, diabetes mellitus, current smoking, antihypertensive medication use, total and high-density lipoprotein cholesterol levels, and hormone replacement therapy in women. A higher DC indicates a more distensible vessel. In women, higher dehydroepiandrosterone (P=0.008) and lower sex hormone-binding globulin (P=0.039) were associated with lower distensibility; higher dehydroepiandrosterone and lower estradiol were associated with smaller carotid diameters. In men, higher Bio-T (P=0.009) and lower estradiol (P=0.007) were associated with greater distensibility and also with smaller diameters (P=0.012 and 0.002, respectively). An androgenic internal milieu is associated with lesser carotid distensibility and diameter remodeling in women, but the opposite is true for men. Higher levels of estradiol are associated with smaller carotid diameters in both the sexes. Future longitudinal and experimental studies are needed to reveal the mechanism and clinical consequences of these associations.

Indexed as

EthnicityAtherosclerosisCarotid Artery, CommonCarotid Intima-Media ThicknessElasticityFemaleGonadal Steroid HormonesHumansIncidenceMaleMiddle AgedPostmenopausePrevalenceRetrospective StudiesRisk FactorsUnited StatesGonadal Steroid Hormonesagingultrasonography

Identifiers

PMID25753974
PMCPMC4394007
OpenAlexW2152486227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.