ArticleJournal of cellular and molecular medicine2015
Association of vitamin D3 with alveolar bone regeneration in dogs.
Article in Journal of cellular and molecular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Does vitamin D have an effect on osseointegration of dental implants? A systematic review.International journal of implant dentistry · 2022Pooled it
- Time-based assessment of local propolis delivery on mid-palatal suture bone formation after rapid maxillary expansion in albino rats.Odontology · 2026Article
- Vitamin D-Loaded Chitosan Nanostructures for Bone Regeneration: A Combined In Vitro and In Vivo Evaluation in an Osteoporotic Rat Model.Medicina (Kaunas, Lithuania) · 2025Article
- The Impact of LDL Cholesterol, HDL Cholesterol, Triglycerides, and Vitamin D on Short-Term Implant Survival Rate: A Prospective Observational Study.Journal of clinical medicine · 2025Article
- Relationship Between the Level of Vitamin D3 Deficiency and Successful Osseointegration: A Prospective Clinical Study.TheScientificWorldJournal · 2024Article
- The role of Vitamin D as an adjunct for bone regeneration: A systematic review of literature.The Saudi dental journal · 2023Review
- Effect of Vitamin D on Bone Regeneration: A Review.Medicina (Kaunas, Lithuania) · 2022Review
- Possible Roles of Vitamin D in Bone Grafting.Cureus · 2021Review
- Assessing the potential use of chitosan scaffolds for the sustained localized delivery of vitamin D.Saudi journal of biological sciences · 2021Article
- Impact of the 25-Hydroxycholecalciferol Concentration and Vitamin D Deficiency Treatment on Changes in the Bone Level at the Implant Site during the Process of Osseointegration: A Prospective, Randomized, Controlled Clinical Trial.Journal of clinical medicine · 2021Article
- [Recent research advances on alveolar ridge preservation after tooth extraction].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2019Article
- Calcitriol exerts a mineralization-inductive effect comparable to that of vitamin C in cultured human periodontium cells.American journal of translational research · 2019Article
- Paracrine interactions between mesenchymal stem cells and macrophages are regulated by 1,25-dihydroxyvitamin D3.Scientific reports · 2017Article
- Isolation of Mesenchymal Stem Cells from Human Deciduous Teeth Pulp.BioMed research international · 2017Article
- Vitamin D deficiency in early implant failure: two case reports.International journal of implant dentistry · 2016Article
- Impact of micronutrients supplementation on bone repair around implants: microCT and counter-torque analysis in rats.Journal of applied oral science : revista FOBArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Designed sockets prepared on the mandibles of nine Beagle dogs were divided into three groups: Calcitriol +Alloplast, Alloplast and Empty. Five of the nine dogs received Vit.D3 and calcium supplement (Vit.D/Ca group), while the other four dogs without supplements were assigned to Non-Vit.D/Ca group. After 4 weeks, the extent of vertical ridge resorption (VRR), bone density (density), new bone formation (NBF) and implant stability quotient (ISQ) were measured. Following systemic Vit.D/Ca administration, the Empty subgroup showed significant differences from the Calcitriol + Alloplast subgroup on variants NBF/Density/VRR and the Alloplast subgroup on items NBF/Density/ISQ/VRR. Alternatively, the Calcitriol + Alloplast subgroup revealed higher values of NBF/Density/ISQ (P < 0.001) and a lower VRR value (P = 0.001) than the Alloplast subgroup. Although there were no significant differences in NBF (P = 0.349), density (P = 0.796), ISQ (P = 0.577) and VRR (0.979) comparisons on alloplast treatment between the Vit.D/Ca and Non-Vit.D/Ca groups, local application with Calcitriol + Alloplast demonstrated better NBF/Density/ISQ (P = 0.02 to <0.001) effects than which of Alloplast subgroups. Consequently, the results showed that both systemic and local vitamin D3 treatment might accelerate bone regeneration in dogs. Within the using dose, systemic vitamin D3 treatment displayed a superior stimulating effect than local vitamin D3 application did.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.