ArticleAntimicrobial agents and chemotherapy2015
In vitro activities of hexaazatrinaphthylenes against Leishmania spp.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Metalloprotease Gp63-Targeting Novel Glycoside Exhibits Potential Antileishmanial Activity.Frontiers in cellular and infection microbiology · 2022Article
- Discovery of New Chemical Tools againstPharmaceuticals (Basel, Switzerland) · 2021Article
- Withanolides fromPathogens (Basel, Switzerland) · 2019Article
- Antileishmanial activity of sulphonamide nanoemulsions targeting the β-carbonic anhydrase from Leishmania species.Journal of enzyme inhibition and medicinal chemistry · 2018Article
- Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil.Parasitology research · 2018Article
- Perifosine Mechanisms of Action in Leishmania Species.Antimicrobial agents and chemotherapy · 2017Article
- Programmed cell death in Acanthamoeba castellanii Neff induced by several molecules present in olive leaf extracts.PloS one · 2017Article
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Authors and funding
8 authors.
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Abstract
The in vitro activity of a novel group of compounds, hexaazatrinaphthylene derivatives, against two species of Leishmania is described in this study. These compounds showed a significant dose-dependent inhibition effect on the proliferation of the parasites, with 50% inhibitory concentrations (IC(50)s) ranging from 1.23 to 25.05 μM against the promastigote stage and 0.5 to 0.7 μM against intracellular amastigotes. Also, a cytotoxicity assay was carried out to in order to evaluate the possible toxic effects of these compounds. Moreover, different assays were performed to determine the type of cell death induced after incubation with these compounds. The obtained results highlight the potential use of hexaazatrinaphthylene derivatives against Leishmania species, and further studies should be undertaken to establish them as novel leishmanicidal therapeutic agents.
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