Evidence map›Paper›PMID 25753632›Full record

ArticleAntimicrobial agents and chemotherapy2015

Complete sequence of a bla(KPC)-harboring cointegrate plasmid isolated from Escherichia coli.

Kalyan D Chavda, Liang Chen, Michael R Jacobs, Albert D Rojtman, Robert A Bonomo, Barry N Kreiswirth

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Clonal dissemination and plasmid plasticity of KPC-3-producing Klebsiella pneumoniae ST512 during a hospital outbreak in Spain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. ISMicrobiology and molecular biology reviews : MMBR · 2024
    Review
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  5. Review
  6. Article
  7. Discovery of small-molecule inhibitors of multidrug-resistance plasmid maintenance using a high-throughput screening approach.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Multidrug-ResistantMicroorganisms · 2020
    Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kalyan D ChavdaPublic Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Liang ChenPublic Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Michael R JacobsDepartment of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio, USA.
Albert D RojtmanDepartment of Pathology, Jersey Shore University Medical Center, Neptune, New Jersey, USA.
Robert A BonomoResearch Service, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA Departments of Medicine, Pharmacology, Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA.
Barry N KreiswirthPublic Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA kreiswba@njms.rutgers.edu.

Funding

The molecular basis of the epidemic blaKPC gene KlebsiellaR01AI090155 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KREISWIRTH, BARRY NEAL · 2011 to 2021
$7.2M
Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
NIAID NIH HHS R01 AI063517NIAID NIH HHS R01AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01AI072219NIAID NIH HHS R01 AI090155NIAID NIH HHS R01AI090155
6 · The paper itself

Abstract

Horizontal transfer of bla(KPC)-harboring plasmids contributes significantly to the inter- and intraspecies spread of Klebsiella pneumoniae carbapenemase (KPC). Here we report the complete nucleotide sequence of a bla(KPC)-harboring IncFIA plasmid, pBK32533, from Escherichia coli. pBK32533 is a cointegrate plasmid comprising of a 72-kb sequence identical to that of the nonconjugative pBK30661 plasmid plus an additional 170-kb element that harbors the genes for plasmid transfer. pBK32533 demonstrates how bla(KPC) can be spread from a nonconjugative plasmid through cointegration.

Indexed as

Bacterial Proteinsbeta-LactamasesEscherichia coliKlebsiella pneumoniaeMicrobial Sensitivity TestsMolecular Sequence DataPlasmidsBacterial Proteinsbeta-Lactamasescarbapenemase

Identifiers

PMID25753632
PMCPMC4394832

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.