ArticleEnvironmental microbiology2015
Biosynthesis of the antifungal haterumalide, oocydin A, in Serratia, and its regulation by quorum sensing, RpoS and Hfq.
Article in Environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
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- Microbial succession and interaction in vacuum-packed beef: a longitudinal study of bacterial and fungal dynamics.NPJ science of food · 2025Article
- The porcine skin microbiome exhibits broad fungal antagonism.Fungal genetics and biology : FG & B · 2024Article
- Modifications of Protein-Bound Substrates by Trans-Acting Enzymes in Natural Products Biosynthesis.Chembiochem : a European journal of chemical biology · 2024Review
- Regulation of indole-3-acetic acid biosynthesis and consequences of auxin production deficiency in Serratia plymuthica.Microbial biotechnology · 2023Article
- Herbicolin A production and its modulation by quorum sensing in a Pantoea agglomerans rhizobacterium bioactive against a broad spectrum of plant-pathogenic fungi.Microbial biotechnology · 2023Article
- The possibility of using Serratia isolates for the production of biopreparations in the protection of plants against diseases and pests.Archives of microbiology · 2023Review
- Biosynthesis of Antifungal Solanimycin May Involve an Iterative Nonribosomal Peptide Synthetase Module.ACS chemical biology · 2023Article
- A natural single nucleotide mutation in the small regulatory RNA ArcZ of Dickeya solani switches off the antimicrobial activities against yeast and bacteria.PLoS genetics · 2023Article
- Article
- The global regulator Hfq exhibits far more extensive and intensive regulation than Crc in Pseudomonas protegens H78.Molecular plant pathology · 2021Article
- Genomic and Phenotypic Biology of Novel Strains ofFrontiers in plant science · 2021Article
- Microfluidic automated plasmid library enrichment for biosynthetic gene cluster discovery.Nucleic acids research · 2020Article
- Improved Prodigiosin Production by Relieving CpxR Temperature-Sensitive Inhibition.Frontiers in bioengineering and biotechnology · 2020Article
- Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing.Angewandte Chemie (International ed. in English) · 2019Article
- Selecting lipopeptide-producing, Fusarium-suppressing Bacillus spp.: Metabolomic and genomic probing of Bacillus velezensis NWUMFkBS10.5.MicrobiologyOpen · 2019Article
- An auxin controls bacterial antibiotics production.Nucleic acids research · 2018Article
- A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones.Angewandte Chemie (International ed. in English) · 2018Article
- Genome Sequence of the Oocydin A-Producing Rhizobacterium Serratia plymuthica 4Rx5.Microbiology resource announcements · 2018Article
- Genome Sequence ofGenome announcements · 2017Article
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Authors and funding
3 authors at 1 institution in 2 countries.
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Abstract
Polyketides represent an important class of bioactive natural products with a broad range of biological activities. We identified recently a large trans-acyltransferase (AT) polyketide synthase gene cluster responsible for the biosynthesis of the antifungal, anti-oomycete and antitumor haterumalide, oocydin A (ooc). Using genome sequencing and comparative genomics, we show that the ooc gene cluster is widespread within biocontrol and phytopathogenic strains of the enterobacteria, Serratia and Dickeya. The analysis of in frame deletion mutants confirmed the role of a hydroxymethylglutaryl-coenzyme A synthase cassette, three flavin-dependent tailoring enzymes, a free-standing acyl carrier protein and two hypothetical proteins in oocydin A biosynthesis. The requirement of the three trans-acting AT domains for the biosynthesis of the macrolide was also demonstrated. Expression of the ooc gene cluster was shown to be positively regulated by an N-acyl-L-homoserine lactone-based quorum sensing system, but operating in a strain-dependent manner. At a post-transcriptional level, the RNA chaperone, Hfq, plays a key role in oocydin A biosynthesis. The Hfq-dependent regulation is partially mediated by the stationary phase sigma factor, RpoS, which was also shown to positively regulate the synthesis of the macrolide. Our results reveal differential regulation of the divergently transcribed ooc transcriptional units, highlighting the complexity of oocydin A production.
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