Evidence map›Paper›PMID 25753493›Full record

Trial reportSpinal cord2015

The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: a clinical trial.

V Mohammadi, M Khalili, S Eghtesadi, S Dehghani, S Jazayeri, S K Aghababaee, H Sabour, H Saberi, M Eghtesadi, M R Gohari

Erratum issuedOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Spinal cord, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. The effect of alpha-lipoic acid supplementation on vascular function and inflammation in patients newly experienced stroke.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

V MohammadiDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
M KhaliliNeurosciences Research Center, Tabriz University of Medical Science, Tabriz, Iran.
S EghtesadiDepartment of Clinical Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
S DehghaniDrug and Poison Information Center, Research and Development Office, Jundishapour University of Medical Sciences, Ahwaz, Iran.
S JazayeriBrain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
S K AghababaeeDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
H SabourBrain and Spinal Injury Repair Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
H SaberiBrain and Spinal Injury Repair Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
M EghtesadiSchool of Medicine, Azad University, Tehran, Iran.
M R GohariDepartment of Biostatistics, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.
Tehran University of Medical Sciences · IRIran University of Medical Sciences · IRAhvaz Jundishapur University of Medical Sciences · IRIslamic Azad University, Tehran · IRUniversity of Tabriz · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designA randomized, double-blind, placebo-controlled clinical trial.

objectiveTo assess the effect of alpha-lipoic acid (ALA) supplementation on IL-6, hs-CRP, FBS, anthropometric indices, food intake and blood pressure in male patients with chronic spinal cord injury (SCI).

settingImam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

methodsFifty-eight men with chronic SCI participated in the study. Participants were divided in two groups: one group received 600 mg of supplemental ALA (n=28) and the other group received placebo (n=30) for 12 weeks. At the beginning and end of the study, biochemical parameters, anthropometric indices, blood pressure and dietary intakes were measured. Dietary intake was measured using N4 software, and statistical analyses were carried out using SPSS16.

resultsNo significant reduction was found in IL-6 (P=0.97) and hs-CRP levels (P=0.23). There was significant reduction in fasting blood sugar (P=0.001), body weight (P=0.001), BMI (P=0.001), waist circumference (P=0.001) and blood pressure (P=0.001). Dietary intake was significantly reduced, including fat (P=0.001), carbohydrate (P=0.001), protein (P=0.002) and energy intakes (P=0.001).

conclusionLipoic acid supplementation had no significant effect on the measured inflammatory markers but it reduces fasting blood sugar, anthropometric parameters, food intake and blood pressure in men with chronic SCI.

Indexed as

AdultAnthropometryBlood Chemical AnalysisBlood GlucoseBlood PressureBody Mass IndexCardiovascular DiseasesDouble-Blind MethodEatingFastingHumansIranMaleRisk FactorsSpinal Cord InjuriesThioctic AcidBlood GlucoseThioctic AcidVitamin B Complex

Identifiers

PMID25753493
OpenAlexW1974052747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.