Evidence map›Paper›PMID 25753492›Full record

ArticleSpinal cord2015

A pilot study on temporal changes in IL-1β and TNF-α serum levels after spinal cord injury: the serum level of TNF-α in acute SCI patients as a possible marker for neurological remission.

B Biglari, T Swing, C Child, A Büchler, F Westhauser, T Bruckner, T Ferbert, H Jürgen Gerner, A Moghaddam

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Spinal cord, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Repurposing of Chemokine Antagonists for Combined Phase-Resolved Spinal Cord Injury Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  7. Review
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  12. Prognostic value of the systemic inflammatory index (SII) and systemic inflammatory response index (SIRI) in patients with traumatic spinal cord injury.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
    Article
  13. Promising Biomarkers for Spinal Cord Injury: A Brief Review.Current trends in biomedical engineering & biosciences · 2024
    Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

B BiglariDepartment of Paraplegiolog, BG Trauma center Ludwigshafen, Ludwigshafen am Rhein, Germany.
T SwingDepartment of Orthopedics, Traumatology, and Paraplegiology, HTRG-Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, Germany.
C ChildDepartment of Orthopedics, Traumatology, and Paraplegiology, HTRG-Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, Germany.
A BüchlerDepartment of Orthopedics, Traumatology, and Paraplegiology, HTRG-Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, Germany.
F WesthauserDepartment of Orthopedics, Traumatology, and Paraplegiology, HTRG-Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, Germany.
T BrucknerInstitute of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Germany.
T FerbertDepartment of Orthopedics, Traumatology, and Paraplegiology, HTRG-Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, Germany.
H Jürgen GernerDepartment of Orthopedics, Traumatology, and Paraplegiology, HTRG-Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, Germany.
A MoghaddamDepartment of Orthopedics, Traumatology, and Paraplegiology, HTRG-Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, Germany.
University Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designSerum levels of interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) were measured over a 12-week period in 23 patients with spinal cord injury (SCI) with and without neurological improvement.

objectivesTo determine the course of IL-1β and TNF-α in patients with SCI and observe a possible relationship between improvements in neurological functioning and cytokine levels.

settingAll patients were treated at the BG Trauma Centre, Ludwigshafen, Germany. All lab work was done at the University Hospital, Heidelberg.

methodsSpinal cord injury was classified according to the American Spinal Injury Association (ASIA) impairment scale (AIS) in 23 patients. TNF-α and IL-1β levels were measured upon arrival at the hospital, after 4 h, 9 h and 12 h, on days 1 and 3 and at the end of weeks 1, 2, 4, 8 and 12.

resultsTemporal changes in TNF-α and IL-1β in SCI patients were seen. Patients with AIS improvement (Group 1) had significantly lower TNF-α levels at 9 h compared with patients without AIS improvement (Group 2; P<0.01). The course of IL-1β fluctuated greatly between 4 h and week 1 in the groups; however, between 2 and 12 weeks post trauma, there was an overall decline in both groups.

conclusionMeasuring serum levels of TNF-α and IL-1β over time could be useful in tracking the course of SCI. Our data show differences in measured cytokines over a 12-week period for SCI patients with and without neurological improvement.

Indexed as

Disease ProgressionAdolescentAdultAgedAged, 80 and overBiomarkersFemaleFollow-Up StudiesHumansInterleukin-1betaMaleMiddle AgedPilot ProjectsRemission InductionSeverity of Illness IndexSpinal Cord InjuriesBiomarkersIL1B protein, humanInterleukin-1betaTNF protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID25753492
OpenAlexW2023476837

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.