ArticleScientific reports2015
Visualization of synaptic domains in the Drosophila brain by magnetic resonance microscopy at 10 micron isotropic resolution.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Experimental demonstration of diffusion limitations on resolution and SNR in MR microscopy.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023Article
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- Advanced high resolution three-dimensional imaging to visualize the cerebral neurovascular network in stroke.International journal of biological sciences · 2022Review
- Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI.Scientific reports · 2021Article
- Probing the brain with molecular fMRI.Current opinion in neurobiology · 2018Review
- Low-temperature magnetic resonance imaging with 2.8 μm isotropic resolution.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- Magnetic Resonance Microscopy (MRM) of Single Mammalian Myofibers and Myonuclei.Scientific reports · 2017Article
- Organization of descending neurons in Drosophila melanogaster.Scientific reports · 2016Article
- Sleep Homeostasis and General Anesthesia: Are Fruit Flies Well Rested after Emergence from Propofol?Anesthesiology · 2016Article
- Micron-scale magnetic resonance imaging of both liquids and solids.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2015Article
- Article
- Micron-scale magnetic resonance imaging based on low temperatures and dynamic nuclear polarization.Progress in nuclear magnetic resonance spectroscopyReview
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3 authors.
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Abstract
Understanding the complex architecture, connectivity, and pathology of the human brain is a major application of magnetic resonance imaging (MRI). However, the cellular basis of MR signal is still poorly understood. The advent of MR microscopy (MRM) enables imaging biological samples at cellular resolution, helping to interpret the nature of MR signal at the cellular level. In this regard, the small Drosophila brain can reveal key aspects of MR signal through the visualization of complex, intact neuronal structures in their native spatial arrangement. Applying state-of-the-art MR technology, we imaged fixed Drosophila heads at 10 μm isotropic resolution by two endogenously contrasted MRM sequences. The improved MRM sensitivity described here delivered the highest 3D resolution of an intact animal head reported so far. 3D fast low angle shot (FLASH) revealed strong signal in most internal tissues, particularly in the brain cortex, which contains the cell bodies of neurons and glia. Remarkably, 3D diffusion weighted imaging (DWI) delivered unprecedented contrast within the modular brain neuropil, revealing hyperintense signal in synapse-rich microdomains. Thus, the complex Drosophila brain revealed unknown features of FLASH and DWI with potential applications in characterizing the structure and pathology of the mammalian brain.
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