ArticleJournal of cellular and molecular medicine2015
Telocytes in minor salivary glands of primary Sjögren's syndrome: association with the extent of inflammation and ectopic lymphoid neogenesis.
Article in Journal of cellular and molecular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Telocytes: history, origin, identification, structure, distribution, and functions.Histochemistry and cell biology · 2025Review
- Submandibular Gland Pathogenesis Following SARS-CoV-2 Infection and Implications for Xerostomia.International journal of molecular sciences · 2024Article
- The Morphology and Ultrastructure of Dermal Telocytes Characterized by TEM and AFM.Cell biochemistry and biophysics · 2024Article
- Identification and protective role of CD34Histochemistry and cell biology · 2023Article
- Identification of PDGFRα+ cells in uterine fibroids - link between angiogenesis and uterine telocytes.Archives of medical science : AMS · 2022Article
- A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland.Dentistry journal · 2021Review
- Impairment in the telocyte/CD34Journal of cellular and molecular medicine · 2021Article
- Resident CD34-positive cells contribute to peri-endothelial cells and vascular morphogenesis in salivary gland after irradiation.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- A Two-Step Immunomagnetic Microbead-Based Method for the Isolation of Human Primary Skin Telocytes/CD34+ Stromal Cells.International journal of molecular sciences · 2020Article
- Immunohistochemical biomarkers and distribution of telocytes in ApoECell biology international · 2019Article
- Expression of toll-like receptors and their regulatory roles in murine cardiac telocytes.Journal of cellular and molecular medicine · 2019Article
- Telocytes constitute a widespread interstitial meshwork in the lamina propria and underlying striated muscle of human tongue.Scientific reports · 2019Article
- Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called "Telocytopathies".Medicina (Kaunas, Lithuania) · 2019Review
- Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis.Frontiers in immunology · 2019Review
- Reappraising the microscopic anatomy of human testis: identification of telocyte networks in the peritubular and intertubular stromal space.Scientific reports · 2018Article
- Morphological evidence of telocytes in human synovium.Scientific reports · 2018Article
- Telocytes in normal and keratoconic human cornea: an immunohistochemical and transmission electron microscopy study.Journal of cellular and molecular medicine · 2017Article
- Telocytes in gastric lamina propria of the Chinese giant salamander, Andrias davidianus.Scientific reports · 2016Article
- Mobilization of lymphatic endothelial precursor cells and lymphatic neovascularization in primary Sjögren's syndrome.Journal of cellular and molecular medicine · 2016Article
- Telocytes in ileum of the Chinese giant salamander: ultrastructural evidence.Journal of cellular and molecular medicine · 2016Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been recently reported that telocytes, a stromal (interstitial) cell subset involved in the control of local tissue homeostasis, are hampered in the target organs of inflammatory/autoimmune disorders. Since no data concerning telocytes in minor salivary glands (MSGs) are currently available, aim of the study was to evaluate telocyte distribution in MSGs with normal architecture, non-specific chronic sialadenitis (NSCS) and primary Sjögren's syndrome (pSS)-focal lymphocytic sialadenitis. Twelve patients with pSS and 16 sicca non-pSS subjects were enrolled in the study. MSGs were evaluated by haematoxylin and eosin staining and immunofluorescence for CD3/CD20 and CD21 to assess focus score, Tarpley biopsy score, T/B cell segregation and germinal center (GC)-like structures. Telocytes were identified by immunoperoxidase-based immunohistochemistry for CD34 and CD34/platelet-derived growth factor receptor α double immunofluorescence. Telocytes were numerous in the stromal compartment of normal MSGs, where their long cytoplasmic processes surrounded vessels and encircled both the excretory ducts and the secretory units. In NSCS, despite the presence of a certain degree of inflammation, telocytes were normally represented. Conversely, telocytes were markedly reduced in MSGs from pSS patients compared to normal and NSCS MSGs. Such a decrease was associated with both worsening of glandular inflammation and progression of ectopic lymphoid neogenesis, periductal telocytes being reduced in the presence of smaller inflammatory foci and completely absent in the presence of GC-like structures. Our findings suggest that a loss of MSG telocytes might have important pathophysiological implications in pSS. The specific pro-inflammatory cytokine milieu of pSS MSGs might be one of the causes of telocyte loss.
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