Evidence map›Paper›PMID 25753421›Full record

ArticleCell reports2015

Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin.

Ralf J Braun, Cornelia Sommer, Christine Leibiger, Romina J G Gentier, Verónica I Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. UBBAging · 2021
    Article
  5. Article
  6. The Dose-Dependent Pleiotropic Effects of the UBBFrontiers in molecular biosciences · 2021
    Review
  7. Editorial: Modeling Neurodegeneration in Yeast.Frontiers in molecular neuroscience · 2021
    Article
  8. Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion.International journal of molecular sciences · 2020
    Review
  9. Article
  10. Recent Insights on Alzheimer's Disease Originating from Yeast Models.International journal of molecular sciences · 2018
    Review
  11. Article
  12. Review
  13. Different Expression Levels of Human Mutant Ubiquitin BFrontiers in molecular neuroscience · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 4 countries.

Ralf J BraunInstitute of Cell Biology, University of Bayreuth, 95440 Bayreuth, Germany. Electronic address: ralf.braun@uni-bayreuth.de.
Cornelia SommerInstitute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria; BioTechMed-Graz, 8010 Graz, Austria.
Christine LeibigerInstitute of Cell Biology, University of Bayreuth, 95440 Bayreuth, Germany.
Romina J G GentierDepartment of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, the Netherlands.
Verónica I DumitFRIAS Freiburg Institute for Advanced Studies, Department of Dermatology, Medical Center, ZBSA Center for Biological Systems Analysis, BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
Katrin PaduchInstitute of Cell Biology, University of Bayreuth, 95440 Bayreuth, Germany.
Tobias EisenbergInstitute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.
Lukas HabernigInstitute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.
Gert TrausingerHEALTH Institute for Biomedicine and Health Sciences, Joanneum Research, 8010 Graz, Austria.
Christoph MagnesHEALTH Institute for Biomedicine and Health Sciences, Joanneum Research, 8010 Graz, Austria.
Thomas PieberHEALTH Institute for Biomedicine and Health Sciences, Joanneum Research, 8010 Graz, Austria; Division of Endocrinology and Metabolism, Medical University of Graz, 8036 Graz, Austria.
Frank SinnerHEALTH Institute for Biomedicine and Health Sciences, Joanneum Research, 8010 Graz, Austria; Division of Endocrinology and Metabolism, Medical University of Graz, 8036 Graz, Austria.
Jörn DengjelFRIAS Freiburg Institute for Advanced Studies, Department of Dermatology, Medical Center, ZBSA Center for Biological Systems Analysis, BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
Fred W van LeeuwenDepartment of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, the Netherlands.
Guido KroemerApoptosis, Cancer and Immunity Laboratory, Team 11, Equipe labellisée Ligue contre le Cancer, INSERM Cordeliers Research Cancer, 75006 Paris, France; Cell Biology and Metabolomics Platforms, Gustave Roussy Comprehensive Cancer Center, 94805 Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75005 Paris, France.
Frank MadeoInstitute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria; BioTechMed-Graz, 8010 Graz, Austria. Electronic address: frank.madeo@uni-graz.at.
Joanneum Research · ATUniversity of Bayreuth · DEUniversity of Graz · ATMaastricht University · NLUniversity of Freiburg · DEBioTechMed-Graz · ATDélégation Paris 5 · FRMedical University of Graz · AT

Funding

Austrian Science Fund FWF I 1000Austrian Science Fund FWF W 1226
6 · The paper itself

Abstract

Neuronal accumulation of UBB

Identifiers

PMID25753421
PMCPMC4407011
OpenAlexW2052962896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.