Evidence map›Paper›PMID 25753415›Full record

ArticleCell reports2015

IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses.

Barbara Platzer, Kutlu G Elpek, Viviana Cremasco, Kristi Baker, Madeleine M Stout, Cornelia Schultz, Eleonora Dehlink, Kai-Ting C Shade, Robert M Anthony, Richard S Blumberg and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 74 citations in OpenAlex.

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  4. Drug allergy history predicts early progression-free survival benefit from PD-(L)1 inhibitors in advanced non-small cell lung cancer: a retrospective cohort study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Barbara PlatzerDivision of Gastroenterology and Nutrition, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Kutlu G ElpekDepartment of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Viviana CremascoDepartment of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Kristi BakerDivision of Gastroenterology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Madeleine M StoutDivision of Gastroenterology and Nutrition, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Cornelia SchultzDivision of Gastroenterology and Nutrition, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Eleonora DehlinkDivision of Gastroenterology and Nutrition, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Kai-Ting C ShadeCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
Robert M AnthonyCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
Richard S BlumbergDivision of Gastroenterology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Shannon J TurleyDepartment of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Edda FiebigerDivision of Gastroenterology and Nutrition, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: edda.fiebiger@childrens.harvard.edu.
Harvard University · USBoston Children's Hospital · USDana-Farber Cancer Institute · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
TCR recognition of MHC class II peptide compexes in multiple sclerosisP01AI045757 · NIAID · DANA-FARBER CANCER INSTITUTE · PI WUCHERPFENNIG, KAI W · 1999 to 2017
$22.8M
INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFER01DK053056 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BLUMBERG, RICHARD S · 1997 to 2021
$10.6M
Role of the gut epithelium in pancreatic autoimmunityR01DK074500 · NIDDK · DANA-FARBER CANCER INST · PI HAINING, WILLIAM NICHOLAS · 2007 to 2016
$3.4M
Postdoctoral Training Program in Cancer ImmunologyT32CA070083 · NCI · DANA-FARBER CANCER INSTITUTE · PI CANTOR, HARVEY · 1997 to 2012
$2.8M
Studies of Fc-epsilon-RI as an antigen presentation structure at mucosal surfacesR01AI075037 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI FIEBIGER, ELISABETH EDDA · 2009 to 2013
$2.0M
Impact of aryl hydrocarbon receptor ligand ingestion on gastrointestinal immunityK01DK093597 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI PLATZER, BARBARA · 2012 to 2015
$625k
Studies on Fc-epsilon-RI as an antigen presentation structure at mucosal surfacesR56AI075037 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI FIEBIGER, ELISABETH EDDA · 2008 to 2008
$423k
Targeting tumor desmoplasia to harness cytotoxic immune responsesR21CA182598 · NCI · DANA-FARBER CANCER INST · PI CREMASCO, VIVIANA · 2014 to 2015
$407k
Studies on the role of FcERI-mediated DC activation in the gastrointestinal tractF32DK081256 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI PLATZER, BARBARA · 2008 to 2010
$121k
Intestinal Immune Regulation by IgG and FcRnR56DK053056 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BLUMBERG, RICHARD S · 2017 to 2017
$100k
NCI NIH HHS R21 CA182598NCI NIH HHS T32 CA070083NIAID NIH HHS P01 AI045757NIAID NIH HHS R01 AI075037NIAID NIH HHS R56 AI075037NIDDK NIH HHS F32 DK081256NIDDK NIH HHS K01 DK093597NIDDK NIH HHS P30 DK034854NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK053056NIDDK NIH HHS R01 DK074500NIDDK NIH HHS R56 DK053056
6 · The paper itself

Abstract

Epidemiologic studies discovered an inverse association between immunoglobulin E (IgE)-mediated allergies and cancer, implying tumor-protective properties of IgE. However, the underlying immunologic mechanisms remain poorly understood. Antigen cross-presentation by dendritic cells (DCs) is of key importance for anti-tumor immunity because it induces the generation of cytotoxic CD8

Identifiers

PMID25753415
PMCPMC4559493
OpenAlexW2069346893

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.