ArticleCell reports2015
Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- The ubiquitin-proteasome system and learning-dependent synaptic plasticity - A 10 year update.Neuroscience and biobehavioral reviews · 2023Review
- Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Insight into the Effects of High-Altitude Hypoxic Exposure on Learning and Memory.Oxidative medicine and cellular longevity · 2022Review
- Homeostatic scaling is driven by a translation-dependent degradation axis that recruits miRISC remodeling.PLoS biology · 2021Article
- Differential regulation of local mRNA dynamics and translation following long-term potentiation and depression.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Neuroproteomics of the Synapse: Subcellular Quantification of Protein Networks and Signaling Dynamics.Molecular & cellular proteomics : MCP · 2021Review
- An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility.Science advances · 2020Article
- Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons.Molecular & cellular proteomics : MCP · 2020Article
- CBeLife · 2020Article
- A Sam68-dependent alternative splicing program shapes postsynaptic protein complexes.The European journal of neuroscience · 2019Article
- Posttranscriptional Gene Regulation of the GABA Receptor to Control Neuronal Inhibition.Frontiers in molecular neuroscience · 2019Article
- Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome.Molecular cell · 2018Article
- Article
- Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease.Seminars in cell & developmental biology · 2018Review
- An Integrative Neuroscience Framework for the Treatment of Chronic Pain: From Cellular Alterations to Behavior.Frontiers in integrative neuroscience · 2018Article
- Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity.Human molecular genetics · 2017Article
- Proteolysis, synaptic plasticity and memory.Neurobiology of learning and memory · 2017Review
- Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat.eLife · 2017Article
- Role of proteasome-dependent protein degradation in long-term operant memory in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Perturbed proteostasis in autism spectrum disorders.Journal of neurochemistry · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Dendritic protein homeostasis is crucial for most forms of long-term synaptic plasticity, and its dysregulation is linked to a wide range of brain disorders. Current models of metabotropic glutamate receptor mediated long-term depression (mGluR-LTD) suggest that rapid, local synthesis of key proteins is necessary for the induction and expression of LTD. Here, we find that mGluR-LTD can be induced in the absence of translation if the proteasome is concurrently inhibited. We report that enhanced proteasomal degradation during the expression of mGluR-LTD depletes dendritic proteins and inhibits subsequent inductions of LTD. Moreover, proteasome inhibition can rescue mGluR-LTD in mice null for the RNA binding protein Sam68, which we show here lack mGluR-dependent translation and LTD. Our study provides mechanistic insights for how changes in dendritic protein abundance regulate mGluR-LTD induction. We propose that Sam68-mediated translation helps to counterbalance degradation, ensuring that protein levels briefly remain above a permissive threshold during LTD induction.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.