ArticleNature communications2015
Cobalt-catalysed site-selective intra- and intermolecular dehydrogenative amination of unactivated sp(3) carbons.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Mechanistic Investigations of Cobalt-Catalyzed, Aminoquinoline-Directed C(spJournal of the American Chemical Society · 2025Article
- Copper-Catalyzed γ-C(spAngewandte Chemie (International ed. in English) · 2025Article
- Synthesis of α-CFACS omega · 2023Article
- Design, Synthesis, and Evaluation of Extended C4-Symmetric Dirhodium Tetracarboxylate Catalysts.ACS catalysis · 2022Article
- Ligand-Enabled β-C(spAngewandte Chemie (International ed. in English) · 2022Article
- Ligand Enabled Pd(II)-Catalyzed γ-C(spJournal of the American Chemical Society · 2021Article
- Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(spChemical reviews · 2021Review
- Intermolecular CDC amination of remote and proximal unactivated CChemical science · 2021Article
- Copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams.RSC advances · 2021Article
- A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactamsChemical science · 2021Article
- Site-selective functionalization of remote aliphatic C-H bondsChemical science · 2020Review
- Insights into Cobalta(III/IV/II)-Electrocatalysis: Oxidation-Induced Reductive Elimination for Twofold C-H Activation.Angewandte Chemie (International ed. in English) · 2020Article
- Co-catalyzedRSC advances · 2019Article
- Catalytic β C-H aminationChemical science · 2019Article
- Heterogeneous Co-catalyzed direct 2-alkylation of azoles with ethers.RSC advances · 2018Article
- Cobalt-catalyzed C(spRSC advances · 2018Article
- Cobalt-catalyzed electrooxidative C-H/N-H [4+2] annulation with ethylene or ethyne.Nature communications · 2018Article
- Complementary Strategies for Directed C(spAngewandte Chemie (International ed. in English) · 2018Review
- Synthetic Approaches toward Monocyclic 3-Amino-β-lactams.ChemistryOpen · 2017Review
- Catalytic Synthesis of N-Heterocycles via Direct C(spJournal of the American Chemical Society · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cobalt-catalysed sp(2) C-H bond functionalization has attracted considerable attention in recent years because of the low cost of cobalt complexes and interesting modes of action in the process. In comparison, much less efforts have been devoted to the sp(3) carbons. Here we report the cobalt-catalysed site-selective dehydrogenative cyclization of aliphatic amides via a C-H bond functionalization process on unactivated sp(3) carbons with the assistance of a bidentate directing group. This method provides a straightforward synthesis of monocyclic and spiro β- or γ-lactams with good to excellent stereoselectivity and functional group tolerance. In addition, a new procedure has been developed to selectively remove the directing group, which enables the synthesis of free β- or γ-lactam compounds. Furthermore, the first cobalt-catalysed intermolecular dehydrogenative amination of unactivated sp(3) carbons is also realized.
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