Evidence map›Paper›PMID 25753171›Full record

ArticleGeneral and comparative endocrinology2015

Developmental timing of perchlorate exposure alters threespine stickleback dermal bone.

Christoff G Furin, Frank A von Hippel, John Postlethwait, C Loren Buck, William A Cresko, Todd M O'Hara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in General and comparative endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Christoff G FurinDepartment of Biological Sciences, University of Alaska Anchorage, 3211 Providence Dr., Anchorage, AK 99508, USA; Department of Biology and Wildlife, University of Alaska Fairbanks, 902 N. Koyukuk Dr., P.O. Box 757000, Fairbanks, AK 99775, USA. Electronic address: bfurin@gmail.com.
Frank A von HippelDepartment of Biological Sciences, University of Alaska Anchorage, 3211 Providence Dr., Anchorage, AK 99508, USA. Electronic address: favonhippel@uaa.alaska.edu.
John PostlethwaitInstitute of Neuroscience, University of Oregon, 1254 University of Oregon 222 Huestis Hall, Eugene, OR 97403, USA. Electronic address: jpostle@uoneuro.uoregon.edu.
C Loren BuckDepartment of Biological Sciences, University of Alaska Anchorage, 3211 Providence Dr., Anchorage, AK 99508, USA. Electronic address: clbuck@uaa.alaska.edu.
William A CreskoInstitute of Ecology and Evolution, University of Oregon, 312 Pacific Hall, Eugene, OR 97403, USA. Electronic address: wcresko@uoregon.edu.
Todd M O'HaraDepartment of Veterinary Medicine, University of Alaska Fairbanks, P.O. Box 757750, Fairbanks, AK 99775-7750, USA. Electronic address: tmohara@alaska.edu.
University of Alaska Anchorage · USUniversity of Alaska Fairbanks · USUniversity of Oregon · US

Funding

The Administrative CoreP20GM103395 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI BRIAN M BARNES · 2012 to 2026
$66.1M
Mechanisms of Perchlorate-Induced Disruption of Sexual DifferentiationR01ES017039 · NIEHS · UNIVERSITY OF ALASKA ANCHORAGE · PI BUCK, CHARLES LOREN, CRESKO, WILLIAM A · 2010 to 2014
$2.7M
NIEHS NIH HHS 1R01ES017039NIEHS NIH HHS R01 ES017039NIGMS NIH HHS P20 GM103395NIGMS NIH HHS P20GM103395
6 · The paper itself

Abstract

Adequate levels of thyroid hormone are critical during development and metamorphosis, and for maintaining metabolic homeostasis. Perchlorate, a common contaminant of water sources, inhibits thyroid function in vertebrates. We utilized threespine stickleback (Gasterosteus aculeatus) to determine if timing of perchlorate exposure during development impacts adult dermal skeletal phenotypes. Fish were exposed to water contaminated with perchlorate (30mg/L or 100mg/L) beginning at 0, 3, 7, 14, 21, 42, 154 or 305days post fertilization until sexual maturity at 1year of age. A reciprocal treatment moved stickleback from contaminated to clean water on the same schedule providing for different stages of initial exposure and different treatment durations. Perchlorate exposure caused concentration-dependent significant differences in growth for some bony traits. Continuous exposure initiated within the first 21days post fertilization had the greatest effects on skeletal traits. Exposure to perchlorate at this early stage can result in small traits or abnormal skeletal morphology of adult fish which could affect predator avoidance and survival.

Indexed as

AnimalsPerchloratesSmegmamorphaThyroid HormonesWater Pollutants, ChemicalperchloratePerchloratesThyroid HormonesWater Pollutants, ChemicalEndocrine disruptionGasterosteus aculeatusHypothyroidismSkeletal abnormalityThyroid hormone

Identifiers

PMID25753171
PMCPMC4508210
OpenAlexW2092071206

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.