ArticleJournal of the American Geriatrics Society2015
Chronic wound repair and healing in older adults: current status and future research.
Article in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03667638 (The Influence of Autologous Platelet Concentrates on Human Keratinocyte Proliferation in Vitro and Wound Healing in Vivo), which is not on this map. Cited by 140 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Influence of Autologous Platelet Concentrates on Human Keratinocyte Proliferation in Vitro and Wound Healing in Vivo
Who cites it
140 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Adipose tissue and fat-derived products in wound, ulcer, and scar management: a systematic review.Frontiers in surgery · 2025Pooled it
- The Efficacy of Stem Cells in Wound Healing: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Comparison of Distal Radius Fracture Outcomes in Older Adults Stratified by Chronologic vs Physiologic Age Managed With Casting vs Surgery.JAMA network open · 2023Trial
- Infectious bacterial keratitis management in a Swedish region: Risk factors, treatment and time-to-resolution.Acta ophthalmologica · 2026Article
- The Zinc-Senescence Axis in Skin Aging and Wound Healing: A Narrative Review.International journal of molecular sciences · 2026Review
- Mechanisms and Clinical Manifestations of Age-Related Impairment in Wound Healing.International wound journal · 2026Review
- Aging alters synergistic microRNA networks in exosomes to stimulate repair in lung injury and skin wound healing.Molecular therapy. Nucleic acids · 2026Article
- Black Sea-Derived Biomaterials for Wound-Healing Applications.International journal of molecular sciences · 2026Article
- Diminished and Altered Cellular Senescence Response in Delayed Wound Healing of Aging.Aging cell · 2026Article
- Unveiling the therapeutic role of 3D-cultured mesenchymal stem cells in diabetic foot ulcers through transcriptomic integration and fibroblast modulation.Molecular biology reports · 2026Article
- Review
- The Role and Efficacy of NovoSorb Biodegradable Temporizing Matrix in Complex Reconstructive Wounds: A Systematic Review.Plastic and reconstructive surgery. Global open · 2026Article
- Liposome-based drug delivery systems for skin wound healing: a promising drug delivery strategy.Frontiers in bioengineering and biotechnology · 2026Review
- Challenging the age barrier: comparative outcomes in octogenarian and non-octogenarian colorectal cancer patients.BMC geriatrics · 2025Article
- Analysis of risk factors for bleeding after gastric endoscopic submucosal dissection with an emphasis on age and sex differences: A nationwide population-based study.Surgical endoscopy · 2025Article
- Therapeutic Effect of Alpha Linolenic Acid on Cutaneous Wound Healing in Hyperglycemic Mice: Involvement of Neurotrophins.Pharmaceutics · 2025Article
- Endothelial Effects in the Elderly: Fibroblast Regulation in Soft Tissue Healing.Journal of cellular physiology · 2025Article
- Comparison of Single Use and Traditional Negative Pressure Wound Therapy Devices in Lower Extremity Ulcers: A US Real-World Evidence Analysis of NetHealth Data.International wound journal · 2025Article
- Developing an AI-powered wound assessment tool: a methodological approach to data collection and model optimization.BMC medical informatics and decision making · 2025Observational
- Optimizing wound healing: insights from phytochemicals and advanced therapies.Inflammopharmacology · 2025Review
80 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Funding
Abstract
Older adults are more likely to have chronic wounds than younger people, and the effect of chronic wounds on quality of life is particularly profound in this population. Wound healing slows with age, but the basic biology underlying chronic wounds and the influence of age-associated changes on wound healing are poorly understood. Most studies have used in vitro approaches and various animal models, but observed changes translate poorly to human healing conditions. The effect of age and accompanying multimorbidity on the effectiveness of existing and emerging treatment approaches for chronic wounds is also unknown, and older adults tend to be excluded from randomized clinical trials. Poorly defined outcomes and variables; lack of standardization in data collection; and variations in the definition, measurement, and treatment of wounds also hamper clinical studies. The Association of Specialty Professors, in conjunction with the National Institute on Aging and the Wound Healing Society, held a workshop, summarized in this article, to explore the current state of knowledge and research challenges, engage investigators across disciplines, and identify research questions to guide future study of age-associated changes in chronic wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.