ArticleScientific reports2015
Diminished appetitive startle modulation following targeted inhibition of prefrontal cortex.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Does non-invasive brain stimulation modulate emotional stress reactivity?Social cognitive and affective neuroscience · 2020Pooled it
- Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2019Pooled it
- The effect of ketamine on affective modulation of the startle reflex and its resting-state brain correlates.Scientific reports · 2023Trial
- Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Pleasant touch perception in borderline personality disorder and its relationship with disturbed body representation.Borderline personality disorder and emotion dysregulation · 2022Article
- Circuit-Targeted Neuromodulation for Anhedonia.Current topics in behavioral neurosciences · 2022Review
- Quantifying defence cascade responses as indicators of pig affect and welfare using computer vision methods.Scientific reports · 2020Article
- Anhedonia across borders: Transdiagnostic relevance of reward dysfunction for noninvasive brain stimulation endophenotypes.CNS neuroscience & therapeutics · 2019Review
- Welfare-improving enrichments greatly reduce hens' startle responses, despite little change in judgment bias.Scientific reports · 2019Article
- Commentary: Modulation of Prepulse Inhibition and Startle Reflex by Emotions: A Comparison between Young and Older Adults.Frontiers in aging neuroscience · 2016Article
- [Experimental and therapeutic neuromodulation of emotion and social cognition with non-invasive brain stimulation].Der Nervenarzt · 2015Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From an evolutionary perspective the startle eye-blink response forms an integral part of the human avoidance behavioral repertoire and is typically diminished by pleasant emotional states. In major depressive disorder (MDD) appetitive motivation is impaired, evident in a reduced interference of positive emotion with the startle response. Given the pivotal role of frontostriatal neurocircuitry in orchestrating appetitive motivation, we hypothesized that inhibitory transcranial magnetic stimulation (TMS) would reduce appetitive neuromodulation in a manner similar to MDD. Based on a pre-TMS functional MRI (fMRI) experiment we selected the left dorsolateral and dorsomedial prefrontal cortices as target regions for subsequent sham-controlled inhibitory theta-burst TMS (TBS) in 40 healthy male volunteers. Consistent with our hypothesis, between-group comparisons revealed a TBS-induced inhibition of appetitive neuromodulation, manifest in a diminished startle response suppression by hedonic stimuli. Collectively, our results suggest that functional integrity of left dorsolateral and dorsomedial prefrontal cortex is critical for mediating a pleasure-induced down-regulation of avoidance responses which may protect the brain from a depressogenic preponderance of defensive stress.
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