Evidence map›Paper›PMID 25752883›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2015

Malnutrition is associated with worse health-related quality of life in children with cancer.

Aeltsje Brinksma, Robbert Sanderman, Petrie F Roodbol, Esther Sulkers, Johannes G M Burgerhof, Eveline S J M de Bont, Wim J E Tissing

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
6.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06730204 narecruitingnot on this mapstarted 2023, after this paper: background citation

Nutrition Strategies and Malnutrition Assessment Management Systems for Preventing Malnutrition in Children With Solid Tumors: an Exploratory Intervention Study

TypeinterventionalSponsorChildren's Hospital of Fudan UniversityRan2023 to 2026Enrolled400ConditionsTumor, Solid, Children, Nutritional InterventionArmsStandardized nutritional management, Standardized nutritional management + short peptide ONS
NCT06846294 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

OBesity PREVention in Children and Young People Treated with ALLtogetheR: Prehabilitation Feasibility Intervention

TypeinterventionalSponsorUniversity of ExeterRan2025 to 2029Enrolled90ConditionsDiet Intervention, Physical Activity Intervention, Standard Care ControlArmsDiet, Diet and physical activity
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. The Association Between Affect and Adiposity in Childhood and Adolescence: A Systematic Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Aeltsje BrinksmaDepartment of Pediatric Oncology and Hematology Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, a.brinksma@umcg.nl.
Robbert Sanderman
Petrie F Roodbol
Esther Sulkers
Johannes G M Burgerhof
Eveline S J M de Bont
Wim J E Tissing
University of Groningen · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMalnutrition in childhood cancer patients has been associated with lower health-related quality of life (HRQOL). However, this association has never actually been tested. Therefore, we aimed to determine the association between nutritional status and HRQOL in children with cancer.

methodsIn 104 children, aged 2-18 years and diagnosed with hematological, solid, or brain malignancies, nutritional status and HRQOL were assessed at diagnosis and at 3, 6, and 12 months using the child- and parent-report versions of the PedsQL 4.0 Generic scale and the PedsQL 3.0 Cancer Module. Scores on both scales range from 0 to 100.

resultsUndernourished children (body mass index (BMI) or fat-free mass < -2 standard deviation score (SDS)) reported significantly lower PedsQL scores compared with well-nourished children on the domains physical functioning (-13.3), social functioning (-7.0), cancer summary scale (-5.9), and nausea (-14.7). Overnourished children (BMI or fat mass >2 SDS) reported lower scores on emotional (-8.0) and cognitive functioning (-9.2) and on the cancer summary scale (-6.6), whereas parent-report scores were lower on social functioning (-7.5). Weight loss (>0.5 SDS) was associated with lower scores on physical functioning (-13.9 child-report and -10.7 parent-report), emotional (-7.4) and social functioning (-6.0) (child-report), pain (-11.6), and nausea (-7.8) (parent-report). Parents reported worse social functioning and more pain in children with weight gain (>0.5 SDS) compared with children with stable weight status.

conclusionsUndernutrition and weight loss were associated with worse physical and social functioning, whereas overnutrition and weight gain affected the emotional and social domains of HRQL. Interventions that improve nutritional status may contribute to enhanced health outcomes in children with cancer.

Indexed as

AdolescentChildChild, PreschoolCohort StudiesFemaleHumansMaleMalnutritionNeoplasmsQuality of Life

Identifiers

PMID25752883
PMCPMC4552776
OpenAlexW1983468870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.