ArticleJournal of cellular physiology2015
Roles for Histone Acetylation in Regulation of Telomere Elongation and Two-cell State in Mouse ES Cells.
Article in Journal of cellular physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Stable maintenance of MERVL-positive embryonic stem cells reveals sustained transcriptional programs and enhancer remodeling.The Journal of biological chemistry · 2026Article
- Stable Maintenance of Two-Cell-Like Cells from Embryonic Stem Cells Reveals Chromatin and Super Enhancer Regulation of MERVL Elements.bioRxiv : the preprint server for biology · 2025Article
- Lactylation of Hdac1 regulated by Ldh prevents the pluripotent-to-2C state conversion.Stem cell research & therapy · 2024Article
- The homeobox transcription factor DUXBL controls exit from totipotency.Nature genetics · 2024Article
- Reprogramming Chromosome Ends by Functional Histone Acetylation.International journal of molecular sciences · 2024Article
- ZSCAN4-binding motif-TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- The regulation of totipotency transcription: Perspective fromFrontiers in cell and developmental biology · 2022Review
- CTCF is a barrier for 2C-like reprogramming.Nature communications · 2021Article
- ZSCAN4EMBO reports · 2020Article
- The role of telomere-binding modulators in pluripotent stem cells.Protein & cell · 2020Review
- Zscan4c activates endogenous retrovirus MERVL and cleavage embryo genes.Nucleic acids research · 2019Article
- From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs.EMBO molecular medicine · 2019Review
- Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program.Genes & development · 2019Article
- BRD4 and Cancer: going beyond transcriptional regulation.Molecular cancer · 2018Review
- Dynamics of Telomere Rejuvenation during Chemical Induction to Pluripotent Stem Cells.Stem cell reports · 2018Article
- Epigenetics of Subcellular Structure Functioning in the Origin of Risk or Resilience to Comorbidity of Neuropsychiatric and Cardiometabolic Disorders.International journal of molecular sciences · 2018Review
- DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells.PloS one · 2017Article
- MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.Cell reports · 2016Article
- Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases.Current allergy and asthma reports · 2015Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Mammalian telomeres and subtelomeres are marked by heterochromatic epigenetic modifications, including repressive DNA methylation and histone methylation (e.g., H3K9me3 and H4K20me3). Loss of these epigenetic marks results in increased rates of telomere recombination and elongation. Other than these repressive epigenetic marks, telomeric and subtelomeric H3 and H4 are underacetylated. Yet, whether histone acetylation also regulates telomere length has not been directly addressed. We thought to test the effects of histone acetylation levels on telomere length using histone deacetylase (HDAC) inhibitor (sodium butyrate, NaB) that mediates histone hyperacetylation and histone acetyltransferase (HAT) inhibitor (C646) that mediates histone hypoacetylation. We show that histone hyperacetylation dramatically elongates telomeres in wild-type ES cells, and only slightly elongates telomeres in Terc(-/-) ES cells, suggesting that Terc is involved in histone acetylation-induced telomere elongation. In contrast, histone hypoacetylation shortens telomeres in both wild-type and Terc(-/-) ES cells. Additionally, histone hyperacetylation activates 2-cell (2C) specific genes including Zscan4, which is involved in telomere recombination and elongation, whereas histone hypoacetylation represses Zscan4 and 2C genes. These data suggest that histone acetylation levels affect the heterochromatic state at telomeres and subtelomeres, and regulate gene expression at subtelomeres, linking histone acetylation to telomere length maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.