ArticleJournal of cellular and molecular medicine2015
The sinus venosus myocardium contributes to the atrioventricular canal: potential role during atrioventricular node development?
Article in Journal of cellular and molecular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
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- Journey to the center of the heart: Bilateral absent superior vena cava with heart block.Global cardiology science & practice · 2020Article
- Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish.JCI insight · 2019Article
- Learn from Your Elders: Developmental Biology Lessons to Guide Maturation of Stem Cell-Derived Cardiomyocytes.Pediatric cardiology · 2019Review
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- Three-Dimensional Portable Document Format (3D PDF) in Clinical Communication and Biomedical Sciences: Systematic Review of Applications, Tools, and Protocols.JMIR medical informatics · 2018Review
- Developmental Origin of the Cardiac Conduction System: Insight from Lineage Tracing.Pediatric cardiology · 2018Review
- Lineages of the Cardiac Conduction System.Journal of cardiovascular development and disease · 2017Review
- Development of the cardiac pacemaker.Cellular and molecular life sciences : CMLS · 2017Review
- Development and Function of the Cardiac Conduction System in Health and Disease.Journal of cardiovascular development and disease · 2017Article
- Does the dorsal mesenchymal protrusion act as a temporary pacemaker during heart development?The Journal of biological chemistry · 2015Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of distinct electrophysiological pathways within the atrioventricular node (AVN) is a prerequisite for atrioventricular nodal reentrant tachycardia to occur. In this study, the different cell contributions that may account for the anatomical and functional heterogeneity of the AVN were investigated. To study the temporal development of the AVN, the expression pattern of ISL1, expressed in cardiac progenitor cells, was studied in sequential stages performing co-staining with myocardial markers (TNNI2 and NKX2-5) and HCN4 (cardiac conduction system marker). An ISL1+/TNNI2+/HCN4+ continuity between the myocardium of the sinus venosus and atrioventricular canal was identified in the region of the putative AVN, which showed a pacemaker-like phenotype based on single cell patch-clamp experiments. Furthermore, qPCR analysis showed that even during early development, different cell populations can be identified in the region of the putative AVN. Fate mapping was performed by in ovo vital dye microinjection. Embryos were harvested and analysed 24 and 48 hrs post-injection. These experiments showed incorporation of sinus venosus myocardium in the posterior region of the atrioventricular canal. The myocardium of the sinus venosus contributes to the atrioventricular canal. It is postulated that the myocardium of the sinus venosus contributes to nodal extensions or transitional cells of the AVN since these cells are located in the posterior region of the AVN. This finding may help to understand the origin of atrioventricular nodal reentrant tachycardia.
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