Evidence map›Paper›PMID 25752778›Full record

Trial reportJournal of the American Geriatrics Society2015

Heterogeneity of physical function responses to exercise training in older adults.

Elizabeth A Chmelo, Charlotte I Crotts, Jill C Newman, Tina E Brinkley, Mary F Lyles, Xiaoyan Leng, Anthony P Marsh, Barbara J Nicklas

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Vitamin DJournal of cachexia, sarcopenia and muscle · 2021
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  15. Change in Bone Mineral Density During Weight Loss with Resistance Versus Aerobic Exercise Training in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
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  18. Article
  19. Aerobic Exercise Training and VOJournal of functional morphology and kinesiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elizabeth A ChmeloJ. Paul Sticht Center on Aging and Rehabilitation, Wake Forest University, Winston-Salem, North Carolina; Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, North Carolina.
Charlotte I Crotts
Jill C Newman
Tina E Brinkley
Mary F Lyles
Xiaoyan Leng
Anthony P Marsh
Barbara J Nicklas

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
Loss of fat tissue and functional responses to exercise in older, obese adultsR01AG020583 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NICKLAS, BARBARA J · 2002 to 2013
$4.0M
Effect of fat loss on functional and cardiovascular benefits of aerobic exerciseR01HL093713 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NICKLAS, BARBARA J · 2009 to 2013
$3.4M
NHLBI NIH HHS R01 HL093713NHLBI NIH HHS R01HL093713NIA NIH HHS P30 AG021332NIA NIH HHS P30AG21332NIA NIH HHS R01 AG020583NIA NIH HHS R01AG020583
6 · The paper itself

Abstract

objectivesTo describe the interindividual variability in physical function responses to supervised resistance and aerobic exercise training interventions in older adults.

designData analysis of two randomized, controlled exercise trials.

settingCommunity-based research centers.

participantsOverweight and obese (body mass index (BMI)≥27.0 kg/m2) sedentary men and women aged 65 to 79 (N=95).

interventionFive months of 4 d/wk of aerobic training (AT, n=40) or 3 d/wk of resistance training (RT, n=55). MEASUREMENTS: Physical function assessments: global measure of lower extremity function (Short Physical Performance Battery (SPPB)), 400-m walk, peak aerobic capacity (VO2 peak), and knee extensor strength.

resultsOn average, both exercise interventions significantly improved physical function. For AT, there was a 7.9% increase in VO2 peak; individual absolute increases varied from 0.4 to 4.3 mL/kg per minute, and four participants (13%) showed no change or a decrease in VO2 peak. For RT, knee extensor strength improved an average of 8.1%; individual increases varied from 1.2 to 63.7 Nm, and 16 participants (30%) showed no change or a decrease in strength. Usual gait speed, 400-m walk time, chair rise time, and SPPB improved for the majority of AT participants and usual gait speed, chair rise time, and SPPB improved for the majority of RT participants, but there was wide variation in the magnitude of improvement. Only change in 400-m walk time with RT was related to exercise adherence (correlation coefficient=-0.31, P=.004).

conclusionDespite sufficient levels of adherence to both exercise interventions, some participants did not improve function, and the magnitude of improvement varied widely. Additional research is needed to identify factors that optimize responsiveness to exercise to maximize its functional benefits in older adults.

Indexed as

Resistance TrainingAgedExerciseFemaleGeriatric AssessmentHumansMaleaerobic trainingmuscle strengthpeak aerobic capacityresistance trainingresponse variability

Identifiers

PMID25752778
PMCPMC4373970

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.