Evidence map›Paper›PMID 25752642›Full record

ArticlePsychological medicine2015

Prefrontal hypoactivation during working memory in bipolar II depression.

J O Brooks, N Vizueta, C Penfold, J D Townsend, S Y Bookheimer, L L Altshuler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

J O BrooksDepartment of Psychiatry & Biobehavioral Sciences,UCLA Semel Institute for Neuroscience & Human Behavior,Los Angeles,CA,USA.
N VizuetaDepartment of Psychiatry & Biobehavioral Sciences,UCLA Semel Institute for Neuroscience & Human Behavior,Los Angeles,CA,USA.
C PenfoldDepartment of Psychiatry & Biobehavioral Sciences,UCLA Semel Institute for Neuroscience & Human Behavior,Los Angeles,CA,USA.
J D TownsendDepartment of Psychiatry & Biobehavioral Sciences,UCLA Semel Institute for Neuroscience & Human Behavior,Los Angeles,CA,USA.
S Y BookheimerDepartment of Psychiatry & Biobehavioral Sciences,UCLA Semel Institute for Neuroscience & Human Behavior,Los Angeles,CA,USA.
L L AltshulerDepartment of Psychiatry & Biobehavioral Sciences,UCLA Semel Institute for Neuroscience & Human Behavior,Los Angeles,CA,USA.
Neurobehavioral Systems · US

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
YALE CENTER FOR THE: LEARNING &ATTENTIONP41RR013642 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARER, ELAINE L · 1998 to 2011
$21.9M
RESEARCH TRAINING: PSYCHOBIOLOGICAL SCIENCEST32MH017140 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEUCHTER, ANDREW F · 1985 to 2012
$3.2M
FMRI IN BIPOLAR ILLNESSK24MH001848 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALTSHULER, LORI L · 2001 to 2010
$1.4M
Tractography, White Matter Integrity and fMRI In Bipolar DisorderR21MH086104 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALTSHULER, LORI L · 2009 to 2010
$428k
Mapping Brain Structure to Function in Bipolar DisorderR21MH075944 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALTSHULER, LORI L · 2006 to 2007
$377k
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR012169 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAZZIOTTA, JOHN C · 1996 to 1997
–
NCRR NIH HHS C06 RR012169NCRR NIH HHS M01 RR000865NCRR NIH HHS P41 RR013642NCRR NIH HHS RR00865NCRR NIH HHS RR13642NIMH NIH HHS K24 MH001848NIMH NIH HHS K24MH01848NIMH NIH HHS R21 MH075944NIMH NIH HHS R21 MH086104NIMH NIH HHS T32 MH017140NIMH NIH HHS T32MH17140
6 · The paper itself

Abstract

backgroundPatterns of abnormal neural activation have been observed during working memory tasks in bipolar I depression, yet the neural changes associated with bipolar II depression have yet to be explored.

methodAn n-back working memory task was administered during a 3T functional magnetic resonance imaging scan in age- and gender-matched groups of 19 unmedicated, bipolar II depressed subjects and 19 healthy comparison subjects. Whole-brain and region-of-interest analyses were performed to determine regions of differential activation across memory-load conditions (0-, 1- and 2-back).

resultsAccuracy for all subjects decreased with higher memory load, but there was no significant group × memory load interaction. Random-effects analyses of memory load indicated that subjects with bipolar II depression exhibited significantly less activation than healthy subjects in left hemispheric regions of the middle frontal gyrus [Brodmann area (BA) 11], superior frontal gyrus (BA 10), inferior parietal lobule (BA 40), middle temporal gyrus (BA 39) and bilateral occipital regions. There was no evidence of differential activation related to increasing memory load in the dorsolateral prefrontal or anterior cingulate cortex.

conclusionsBipolar II depression is associated with hypoactivation of the left medio-frontal and parietal cortex during working memory performance. Our findings suggest that bipolar II depression is associated with disruption of the fronto-parietal circuit that is engaged in working memory tasks, which is a finding reported across bipolar subtypes and mood states.

Indexed as

AdultBipolar DisorderBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMemory, Short-TermPrefrontal CortexReproducibility of Resultsworking memory

Identifiers

PMID25752642
PMCPMC5110929
OpenAlexW2170981051

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.