SynthesisThe pharmacogenomics journal2015
Tag SNPs for HLA-B alleles that are associated with drug response and disease risk in the Chinese Han population.
Synthesis in The pharmacogenomics journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- An Inexpensive and Quick Method for Genotyping of HLA Variants Included in the Spanish Pharmacogenomic Portfolio of National Health System.International journal of molecular sciences · 2024Article
- Integrative analysis of risk factors for immune-related adverse events of checkpoint blockade therapy in cancer.Nature cancer · 2023Article
- Association of HLA-B22 serotype with SARS-CoV-2 susceptibility in Hong Kong Chinese patients.HLA · 2021Article
- Validation of Single Nucleotide Variant Assays for Human Leukocyte Antigen HaplotypesFrontiers in pharmacology · 2021Article
- Single-nucleotide polymorphisms ofWorld journal of gastroenterology · 2020Article
- Cross-ethnicity tagging SNPs for HLA alleles associated with adverse drug reaction.The pharmacogenomics journal · 2019Article
- A Screening Test forFrontiers in pharmacology · 2019Article
- SNP-based HLA allele tagging, imputation and association with antiepileptic drug-induced cutaneous reactions in Hong Kong Han Chinese.The pharmacogenomics journal · 2018Article
- Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups.Genetics and molecular biologyArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple HLA-B alleles (haplotypes) are associated with drug-induced adverse responses and disease risks but are difficult to be directly genotyped. The goal of this study is to identify single nucleotide polymorphisms (SNPs) that are able to tag HLA-B alleles in the Chinese Han population. Twelve HLA-B alleles that are associated with drug adverse responses and disease risks were identified. They were sequenced initially in 880 Chinese Han subjects where high-density SNPs within the HLA-B gene were available. Performances of these SNPs to tag the HLA-B alleles were assessed primarily by sensitivity and specificity. Two HLA-B alleles can be reliably tagged by SNPs at 100% sensitivity and >95% specificity. For example, HLA-B*15:02 can be tagged by the 'C' allele of rs10484555, and HLA-B*58:01 can be tagged by the 'T' allele of rs9262570. These results were confirmed in 500 additional Chinese Han subjects. If confirmed in independent studies, these tag SNPs could be used as a reliable, simple and cost-effective alternative for genotyping a subset of HLA-B alleles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.