Trial reportMagnetic resonance in medicine2016
Assessment of lymphatic impairment and interstitial protein accumulation in patients with breast cancer treatment-related lymphedema using CEST MRI.
Trial report in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02611557 (Imaging Noninvasively With Functional-MRI for Onset, Response and Management of Lymphatic Impairment), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Imaging Noninvasively With Functional-MRI for Onset, Response and Management of Lymphatic Impairment
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Diagnosis of Upper Quadrant Lymphedema Secondary to Cancer: Clinical Practice Guideline From the Oncology Section of the American Physical Therapy Association.Physical therapy · 2017Guideline
- JointTomography (Ann Arbor, Mich.) · 2024Article
- Development and Validation of Four Different Methods to Improve MRI-CEST Tumor pH Mapping in Presence of Fat.Journal of imaging · 2024Article
- In vivo lymph node CEST-Dixon MRI in breast cancer patients with metastatic lymph node involvement.Magnetic resonance in medicine · 2024Article
- Biogenic Imaging Contrast Agents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Chemical exchange saturation transfer imaging of creatine, phosphocreatine, and protein arginine residue in tissues.NMR in biomedicine · 2023Review
- CEST-MRI for body oncologic imaging: are we there yet?NMR in biomedicine · 2023Review
- Under recognition and treatment of lymphedema in head and neck cancer survivors - a database study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Whole-brain steady-state CEST at 3 T using MR Multitasking.Magnetic resonance in medicine · 2022Article
- In vivo hyperCEST imaging: Experimental considerations for a reliable contrast.Magnetic resonance in medicine · 2022Article
- Baseline Amide Proton Transfer Imaging at 3T Fails to Predict Early Response to Induction Chemotherapy in Nasopharyngeal Carcinoma.Frontiers in oncology · 2022Article
- Elevated magnetic resonance imaging measures of adipose tissue deposition in women with breast cancer treatment-related lymphedema.Breast cancer research and treatment · 2022Article
- A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging.International journal of molecular sciences · 2021Review
- Feasibility evaluation of amide proton transfer-weighted imaging in the parotid glands: a strategy to recognize artifacts and measure APT value.Quantitative imaging in medicine and surgery · 2021Article
- Identification of Tumor-Specific MRI Biomarkers Using Machine Learning (ML).Diagnostics (Basel, Switzerland) · 2021Review
- Standardization of lower extremity quantitative lymphedema measurements and associated patient-reported outcomes in gynecologic cancers.Gynecologic oncology · 2021Review
- Effectiveness of fat suppression using a water-selective binomial-pulse excitation in chemical exchange saturation transfer (CEST) magnetic resonance imaging.Magma (New York, N.Y.) · 2020Article
- Magnetic resonance imaging and bioimpedance evaluation of lymphatic abnormalities in patients with breast cancer treatment-related lymphedema.Breast cancer research and treatment · 2020Article
- CEST MRI quantification procedures for breast cancer treatment-related lymphedema therapy evaluation.Magnetic resonance in medicine · 2020Article
- Current and Emerging Magnetic Resonance-Based Techniques for Breast Cancer.Frontiers in medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeLymphatic impairment is known to reduce quality of life in some of the most crippling diseases of the 21st century, including obesity, lymphedema, and cancer. However, the lymphatics are not nearly as well-understood as other bodily systems, largely owing to a lack of sensitive imaging technologies that can be applied using standard clinical equipment. Here, proton exchange-weighted MRI is translated to the lymphatics in patients with breast cancer treatment-related lymphedema (BCRL).
methodsHealthy volunteers (N = 8) and BCRL patients (N = 7) were scanned at 3 Tesla using customized structural MRI and amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI in sequence with the hypothesis that APT effects would be elevated in lymphedematous tissue. APT contrast, lymphedema stage, symptomatology, and histology information were evaluated.
resultsNo significant difference between proton-weighted APT contrast in the right and left arms of healthy controls was observed. An increase in APT contrast in the affected arms of patients was found (P = 0.025; Cohen's d = 2.4), and variability among patients was consistent with documented damage to lymphatics as quantified by lymphedema stage.
conclusionAPT CEST MRI may have relevance for evaluating lymphatic impairment in patients with BCRL, and may extend to other pathologies where lymphatic compromise is evident.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.