Evidence map›Paper›PMID 25752359›Full record

ReviewExpert review of proteomics2015

Spatial and temporal dynamics of the cardiac mitochondrial proteome.

Edward Lau, Derrick Huang, Quan Cao, T Umut Dincer, Caitie M Black, Amanda J Lin, Jessica M Lee, Ding Wang, David A Liem, Maggie P Y Lam and 1 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert review of proteomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Edward LauDepartment of Physiology, The NHLBI Proteomics Center at UCLA, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Derrick Huang
Quan Cao
T Umut Dincer
Caitie M Black
Amanda J Lin
Jessica M Lee
Ding Wang
David A Liem
Maggie P Y Lam
Peipei Ping
University of California, Los Angeles · US

Funding

TRAININGU54GM114833 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LINDSEY, MERRY L., PING, PEIPEI · 2014 to 2017
$13.8M
Novel Signaling Mechanisms and Molecular Targets in the Stressed MyocardiumR01HL098954 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PING, PEIPEI, WANG, YIBIN · 2010 to 2013
$3.0M
PKC epsilon and Src PTK Signaling in PreconditioningR37HL063901 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PING, PEIPEI · 2010 to 2016
$2.7M
Training in Molecular, Cellular &Integrative PhysiologyT32GM065823 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2003 to 2017
$2.1M
Hexokinases and CardioprotectionR01HL117385 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PING, PEIPEI, WEISS, JAMES N · 2013 to 2016
$1.9M
Mitochondrial Dynamics In Healthy and Diseased MyocardiumR01HL123060 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PING, PEIPEI · 2014 to 2016
$1.1M
Regulation of Protein Dynamics in Heart FailureR01HL129723 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PING, PEIPEI · 2015 to 2016
$1.0M
NHLBI NIH HHS HHSN268201000035CNHLBI NIH HHS R01 HL098954NHLBI NIH HHS R01 HL117385NHLBI NIH HHS R01 HL123060NHLBI NIH HHS R01HL123060NHLBI NIH HHS R01 HL129723NHLBI NIH HHS R37 HL063901NHLBI NIH HHS R37HL063901NIGMS NIH HHS T32 GM065823NIGMS NIH HHS U54 GM114833
6 · The paper itself

Abstract

Mitochondrial proteins alter in their composition and quantity drastically through time and space in correspondence to changing energy demands and cellular signaling events. The integrity and permutations of this dynamism are increasingly recognized to impact the functions of the cardiac proteome in health and disease. This article provides an overview on recent advances in defining the spatial and temporal dynamics of mitochondrial proteins in the heart. Proteomics techniques to characterize dynamics on a proteome scale are reviewed and the physiological consequences of altered mitochondrial protein dynamics are discussed. Lastly, we offer our perspectives on the unmet challenges in translating mitochondrial dynamics markers into the clinic.

Indexed as

AnimalsBiomarkersHumansMitochondriaMitochondrial ProteinsMyocardiumProteomeProteomicsBiomarkersMitochondrial ProteinsProteomecardiovascular diseasemitochondriaprotein dynamicsspatial dynamicstemporal dynamics

Identifiers

PMID25752359
PMCPMC4721584
OpenAlexW2121937148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.