ReviewAnnals of the New York Academy of Sciences2015
Glia: guardians, gluttons, or guides for the maintenance of neuronal connectivity?
Review in Annals of the New York Academy of Sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Neuron-Glial Interactions: Implications for Plasticity, Behavior, and Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Network synchronization deficits caused by dementia and Alzheimer's disease serve as topographical biomarkers: a pilot study.Brain structure & function · 2022Article
- Article
- A Subpopulation of Microglia Generated in the Adult Mouse Brain Originates from Prominin-1-Expressing Progenitors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Danaid Theory of Aging.Frontiers in cell and developmental biology · 2021Review
- Tissue-specific extracellular matrix accelerates the formation of neural networks and communities in a neuron-glia co-culture on a multi-electrode array.Scientific reports · 2019Article
- Astrocytic miR-324-5p is essential for synaptic formation by suppressing the secretion of CCL5 from astrocytes.Cell death & disease · 2019Article
- GATA3 Promotes the Neural Progenitor State but Not Neurogenesis in 3D Traumatic Injury Model of Primary Human Cortical Astrocytes.Frontiers in cellular neuroscience · 2019Article
- Effects of ganoderic acid A on lipopolysaccharide-induced proinflammatory cytokine release from primary mouse microglia cultures.Experimental and therapeutic medicine · 2018Article
- Is Alzheimer's Also a Stem Cell Disease? - The Zebrafish Perspective.Frontiers in cell and developmental biology · 2018Article
- Test-retest reliability and concurrent validity of in vivo myelin content indices: Myelin water fraction and calibrated THuman brain mapping · 2017Article
- Lysine Acetylation and Deacetylation in Brain Development and Neuropathies.Genomics, proteomics & bioinformatics · 2017Review
- Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- The effects of aging on Amyloid-β42-induced neurodegeneration and regeneration in adult zebrafish brain.Neurogenesis (Austin, Tex.) · 2017Article
- Review
- Defining the Microglia Response during the Time Course of Chronic Neurodegeneration.Journal of virology · 2015Article
- Microglia processes associate with diffusely injured axons following mild traumatic brain injury in the micro pig.Journal of neuroinflammation · 2015Article
- Natural Compounds from Saffron and Bear Bile Prevent Vision Loss and Retinal Degeneration.Molecules (Basel, Switzerland) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
An emerging aspect of neuronal-glial interactions is the connection glial cells have to synapses. Mounting research now suggests a far more intimate relationship than previously recognized. Moreover, the current evidence implicating synapse loss in neurodegenerative disease etiology is overwhelming, but the role of glia in the process of synaptic degeneration has only recently been considered in earnest. Each main class of glial cell, including astrocytes, oligodendrocytes, and microglia, performs crucial and multifaceted roles in the maintenance of synaptic function and excitability. As such, aging and/or neuronal stress from disease-related misfolded proteins may involve disruption of multiple non-cell-autonomous synaptic support systems that are mediated by neighboring glia. In addition, glial cell activation induced by injury, ischemia, or neurodegeneration is thought to greatly alter the behavior of glial cells toward neuronal synapses, suggesting that neuroinflammation potentially contributes to synapse loss primarily mediated by altered glial functions. This review discusses recent evidence highlighting novel roles for glial cells at neuronal synapses and in the maintenance of neuronal connectivity, focusing primarily on their implications for neurodegenerative disease research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.