SynthesisIntensive care medicine2015
Mechanical ventilation during extracorporeal life support (ECLS): a systematic review.
Synthesis in Intensive care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis : Mechanical ventilation during ECMO.Intensive care medicine · 2016Pooled it
- ARDS management beyond the guidelines: a practical physiology-based approach to individualized care.Intensive care medicine · 2026Review
- Predictors of VV-ECMO weaning safety: longitudinal ventilatory ratio assessment during sweep gas off trials, a retrospective cohort study.BMC anesthesiology · 2025Article
- Gene expression profiles in respiratory settings in rats under extracorporeal membrane oxygenation.Journal of thoracic disease · 2025Article
- Respiratory extracorporeal membrane oxygenation : From rescue therapy to standard tool for treatment of acute respiratory distress syndrome?Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Extracorporeal Membrane Oxygenation for Respiratory Failure: A Narrative Review.Journal of clinical medicine · 2024Review
- Management of severe acute respiratory distress syndrome: a primer.Critical care (London, England) · 2023Review
- Extracorporeal Membrane Oxygenation in Acute Respiratory Failure.Pulmonary therapy · 2023Review
- Transesophageal Echocardiography-Guided Extracorporeal Membrane Oxygenation Cannulation in COVID-19 Patients.Journal of cardiothoracic and vascular anesthesia · 2022Article
- Ventilation Strategies During Extracorporeal Membrane Oxygenation for Neonatal Respiratory Failure: Current Approaches Among Level IV Neonatal ICUs.Critical care explorations · 2022Article
- Mechanical Ventilation during Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome: A Narrative Review.Journal of clinical medicine · 2021Review
- Procollagen I and III as Prognostic Markers in Patients Treated with Extracorporeal Membrane Oxygenation: A Prospective Observational Study.Journal of clinical medicine · 2021Article
- The Evolution of the Use of Extracorporeal Membrane Oxygenation in Respiratory Failure.Membranes · 2021Review
- Ventilatory management of patients on ECMO.Indian journal of thoracic and cardiovascular surgery · 2021Article
- Bedside troubleshooting during venovenous extracorporeal membrane oxygenation (ECMO).Journal of thoracic disease · 2019Review
- Extracorporeal membrane oxygenation: a literature review.Revista Brasileira de terapia intensiva · 2019Review
- Mechanical ventilation and respiratory monitoring during extracorporeal membrane oxygenation for respiratory support.Annals of translational medicine · 2018Review
- ARDS: challenges in patient care and frontiers in research.European respiratory review : an official journal of the European Respiratory Society · 2018Review
- Ventilation during extracorporeal support : Why and how.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2018Review
- Dynamic driving pressure associated mortality in acute respiratory distress syndrome with extracorporeal membrane oxygenation.Annals of intensive care · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn patients with acute respiratory distress syndrome (ARDS), extracorporeal life support (ECLS) has been utilized to support gas exchange and mitigate ventilator-induced lung injury (VILI). The optimal ventilation settings while on ECLS are unknown. The purpose of this systematic review is to describe the ventilation practices in patients with ARDS who require ECLS.
methodsWe electronically searched MEDLINE, EMBASE, CENTRAL, AMED, and HAPI (inception to January 2015). Studies included were randomized controlled trials, observational studies, or case series (≥4 patients) of ARDS patients undergoing ECLS. Our review focused on studies describing ventilation practices employed during ECLS for ARDS.
resultsForty-nine studies (2,042 patients) met our inclusion criteria. Prior to initiation of ECLS, at least one parameter consistent with injurious ventilation [tidal volume >8 mL/kg predicted body weight (PBW), peak pressure >35 cmH2O (or plateau pressure >30 cmH2O), or FiO2 ≥0.8] was noted in 90% of studies. After initiation of ECLS, studies reported median [interquartile range (IQR)] reductions in: tidal volume [2.4 mL/kg PBW (2.2-2.9)], plateau pressure [4.3 cmH2O (3.5-5.8)], positive end-expiratory pressure (PEEP) [0.20 cmH2O (0-3.0)], and FiO2 [0.40 (0.30-0.60)]. Median (IQR) overall mortality was 41 % (31-51%).
conclusionsReduction in the intensity of mechanical ventilation in patients with ARDS supported by ECLS is common, suggesting that clinicians may be focused on reducing VILI after ECLS initiation. Future investigations should focus on establishing the optimal ventilatory strategy for patients with ARDS who require ECLS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.