ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2016
Endoscopic and histological features of gastric cancers after successful Helicobacter pylori eradication therapy.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71 citing papers in PubMed, 113 citations in OpenAlex.
- Diagnostic performance of magnifying endoscopy with third-generation narrow-band imaging for early gastric cancer: post hoc analysis of a randomized trial (3G detection trial).Journal of gastroenterology · 2026Trial
- Preoperative H. pylori Eradication Therapy Facilitates Precise Delineation in Early Gastric Cancer with Current H. pylori Infection.Digestive diseases (Basel, Switzerland) · 2024Trial
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- Integrated endoscopy: a new method for improving the diagnostic accuracy ofGastroenterology report · 2026Article
- Development and validation of a nomogram incorporating dietary factors for predictingWorld journal of gastroenterology · 2025Article
- Kyoto Classification-Based Predictive Factors Associated with the Development of Gastric Cancer AfterDiagnostics (Basel, Switzerland) · 2025Article
- Conventional Upper-Intestinal Endoscopy Value in Predicting Histopathological Features Related toJGH open : an open access journal of gastroenterology and hepatology · 2025Article
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- Short-term endoscopic alterations of early gastric cancer after successful eradication of Helicobacter pylori.BMC gastroenterology · 2025Article
- Characteristics of Early Gastric Cancer in a Patient with a History of Helicobacter pylori Infection and No History of Eradication Therapy.Internal medicine (Tokyo, Japan) · 2025Article
- Comparison of Genetic Mutations of Gastric Cancer Diagnosed before or after Helicobacter pylori Eradication and between Differentiated and Undifferentiated Types Using Next-Generation Sequencing.Digestive diseases (Basel, Switzerland) · 2025Article
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- Helicobacter pylori infection increases risk of bleeding during endoscopic submucosal dissection for early gastric cancer.Surgical endoscopy · 2024Article
- Gastric carcinoma of the fundic gland type developed 32 years afterAnnals of medicine and surgery (2012) · 2024Article
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- Effect of Helicobacter pylori eradication evaluated using magnifying endoscopy with narrow-band imaging in mixed-type early gastric Cancer.BMC gastroenterology · 2023Article
- Characteristic analysis of early gastric cancer afterAnnals of medicine · 2023Article
- Deep learning based depth map estimation of protoporphyrin IX in turbid media using dual wavelength excitation fluorescence.Biomedical optics express · 2023Article
11 more citing papers are in PubMed but not listed here.
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3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric cancer after successful Helicobacter pylori eradication therapy is often difficult to diagnose by endoscopy because of its indistinct borderline or lack of obviously cancerous characteristics. Furthermore, it has become evident that non-neoplastic epithelium covers cancerous areas in gastric cancer after eradication. Here, we investigated these endoscopic features and their relationship to histological findings.
methodsWe studied 24 and 47 gastric cancers in patients who had (eradication group) and had not (control group) undergone H. pylori eradication, respectively. A gastritis-like appearance revealed by conventional endoscopy was defined as a mucosal pattern with no marked difference from the surrounding non-cancerous area and that revealed by narrow-band imaging (NBI)-magnifying endoscopy (ME) as the mucosal pattern observed in H. pylori-associated atrophic gastritis. We investigated a gastritis-like appearance revealed by conventional endoscopy (A), a gastritis-like appearance at the margin (B) and within (C) the cancerous area revealed by NBI-ME, and the histological characteristics of the overlying non-neoplastic epithelium. We also evaluated the relationship between endoscopic and histological findings in the eradication group.
resultsEndoscopy showed that features A, B and C were significantly more frequent in the eradication group (P = 0.031, P < 0.001, P < 0.001, respectively). Non-neoplastic epithelium covered more than 10 % of the cancerous area more frequently in the eradication group. In the eradication group, more than 90 % of cancers showing a gastritis-like appearance had non-neoplastic epithelium extending over 10 % of the cancerous area.
conclusionGastric cancer after successful H. pylori eradication tends to have gastritis-like features due to non-neoplastic epithelium covering the cancerous tissue.
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