ArticlePloS one2015
Prevalence and correlation of infectious agents in hospitalized children with acute respiratory tract infections in Central China.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2018Pooled it
- Post-COVID-19 Dynamics of Pediatric Respiratory Viruses in Wuhan: Epidemiology, Co-Infection Patterns, and Clinical Severity (2023-2024).Infection and drug resistance · 2026Article
- Development of a multiplex real-time RT-PCR assay for simultaneous detection of 18 respiratory viruses.Frontiers in cellular and infection microbiology · 2025Article
- SARS-CoV-2 Infection Among Children in Rondônia, Western Brazilian Amazon: SARS-CoV-2 Among Children in Rondônia.Advances in virology · 2025Article
- A comprehensive review ofFrontiers in medicine · 2024Review
- Q Fever as a Cause of Community-Acquired Pneumonia in French Guiana.The American journal of tropical medicine and hygiene · 2022Article
- Causes of Lower Respiratory Tract Infections and the Use of Diagnostic Biomarkers in Blood Samples from Children in Hohhot, Inner Mongolia, China, Between July 2019 and June 2020.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Antibodies against atypical pathogens and respiratory viruses detected by Pneumoslide IgM test in adults with community-acquired pneumonia in Guangzhou City.Journal of clinical laboratory analysis · 2020Article
- Unnecessary antimicrobial prescribing for upper respiratory tract infections in children in Pietermaritzburg, South Africa.African health sciences · 2020Article
- High frequency of Chlamydia pneumoniae and risk factors in children with acute respiratory infection.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Impact and clinical profiles of Mycoplasma pneumoniae co-detection in childhood community-acquired pneumonia.BMC infectious diseases · 2019Article
- Diversity of upper respiratory tract infections and prevalence of Streptococcus pneumoniae colonization among patients with fever and flu-like symptoms.BMC infectious diseases · 2019Article
- The prevalence of respiratory pathogens in adults with community-acquired pneumonia in an outpatient cohort.Infection and drug resistance · 2019Article
- Epidemiology and clinical characteristics of acute respiratory tract infections among hospitalized infants and young children in Chengdu, West China, 2009-2014.BMC pediatrics · 2018Article
- Childhood community-acquired pneumonia: A review of etiology- and antimicrobial treatment studies.Paediatric respiratory reviews · 2018Review
- A retrospective seroepidemiologic survey of Chlamydia pneumoniae infection in patients in Beijing between 2008 and 2017.PloS one · 2018Article
- Clinical evaluation of a new single-tube multiplex reverse transcription PCR assay for simultaneous detection of 11 respiratory viruses, Mycoplasma pneumoniae and Chlamydia in hospitalized children with acute respiratory infections.Diagnostic microbiology and infectious disease · 2017Article
- High Prevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae in Children with Acute Respiratory Infections from Lima, Peru.PloS one · 2017Article
- Community-Acquired Pneumonia in the Asia-Pacific Region.Seminars in respiratory and critical care medicine · 2016Review
- Epidemiological and clinical characteristics of respiratory viral infections in children in Shanghai, China.Archives of virology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute respiratory tract infections (ARTIs) are associated with significant morbidity and mortality worldwide, especially in children under the age of 5 years. Almost 2 million children die from ARTIs each year, and most of them are from developing countries. The prevalence and correlation of pathogens in ARTIs are poorly understood, but are critical for improving case prevention, treatment, and management. In this study, we investigated the prevalence and correlation of infectious agents in children with ARTIs. A total of 39,756 children with one or more symptoms, including fever, cough, sore throat, tonsillitis, pharyngitis, herpangina, pneumonia, and bronchiolitis, were enrolled in the study. All patients were hospitalized in Wuhan Children's Hospital between October 1, 2010 and September 30, 2012, and were evaluated for infectious agents. Pathogens, including Mycoplasma pneumoniae, influenza A virus, influenza B virus, adenoviruses, respiratory syncytial virus, parainfluenza virus, Legionella pneumophila, Chlamydophila pneumoniae, and Coxiella burnetii, were screened simultaneously in patient blood samples using anti-pathogen IgM tests. Regression analysis was used to reveal correlations among the pathogens. Our results showed that one or more pathogens were identified in 10,206 patients, and that Mycoplasma pneumoniae, adenoviruses, and influenza B virus were the leading infectious agents. Mixed-infections of pathogens were detected in 2,391 cases, with Mycoplasma pneumoniae as the most frequent pathogen. The most common agents in the co-infections were Mycoplasma pneumoniae and influenza B virus. Regression analysis revealed a linear correlation between the proportion of mixed infections and the incidence of multi-pathogen infections. The prevalence of infectious agents in children with ARTIs was determined. Equations were established to estimate multiple infections by single-pathogen detection. This revealed a linear correlation for pathogens in children with ARTIs. This study provides useful information for improving case prevention and management.
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