ArticleJournal of biomedical optics2015
Quantitative optical coherence tomography imaging of intermediate flow defect phenotypes in ciliary physiology and pathophysiology.
Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology.Developmental cell · 2026Article
- Straining Flow Effects on Sperm Flagellar Energetics in Microfluidic Cross-Slot Traps.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Optical Imaging of Cilia in the Head and Neck.Journal of clinical medicine · 2025Review
- Article
- CFAP45, a heterotaxy and congenital heart disease gene, affects cilia stability.Developmental biology · 2023Article
- OCT particle tracking velocimetry of biofluids in a microparallel plate strain induction chamber.Journal of biomedical optics · 2021Article
- Gaussian process post-processing for particle tracking velocimetry.Biomedical optics express · 2019Article
- Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography.Scientific reports · 2017Article
- Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging.Optics express · 2017Article
- Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography.Lasers in surgery and medicine · 2017Article
- Analysis of Craniocardiac Malformations in Xenopus using Optical Coherence Tomography.Scientific reports · 2017Article
- Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows.Biomedical optics express · 2016Article
- Measurement of ciliary beat frequency using Doppler optical coherence tomography.International forum of allergy & rhinology · 2015Article
- Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography.Biomedical optics express · 2015Article
- In vivo micro-scale tomography of ciliary behavior in the mammalian oviduct.Scientific reports · 2015Article
- Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography.Journal of biomedical optics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cilia-driven fluid flow is a critical yet poorly understood aspect of pulmonary physiology. Here, we demonstrate that optical coherence tomography-based particle tracking velocimetry can be used to quantify subtle variability in cilia-driven flow performance in Xenopus, an important animal model of ciliary biology. Changes in flow performance were quantified in the setting of normal development, as well as in response to three types of perturbations: mechanical (increased fluid viscosity), pharmacological (disrupted serotonin signaling), and genetic (diminished ciliary motor protein expression). Of note, we demonstrate decreased flow secondary to gene knockdown of kif3a, a protein involved in ciliogenesis, as well as a dose-response decrease in flow secondary to knockdown of dnah9, an important ciliary motor protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.