Evidence map›Paper›PMID 25750931›Full record

ArticleCurrent opinion in behavioral sciences2015

Memory integration: neural mechanisms and implications for behavior.

Margaret L Schlichting, Alison R Preston

Registry-linked trialAbstract read
In one paragraph

Article in Current opinion in behavioral sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05910762 (Learning Novel Structure Across Time and Sleep), which is not on this map. Cited by 202 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05910762 nacompletednot on this mapstarted 2023, after this paper: background citation

Learning Novel Structure Across Time and Sleep

TypeinterventionalSponsorUniversity of PennsylvaniaRan2023 to 2026Enrolled119ConditionsLearning, Humans, Consolidation, SleepArmsAssociative inference, Category learning, Sleep
3 · Its place in the literature

Who cites it

202 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Memory reactivation during rest supports upcoming learning of related content.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Trial
  6. The next generation of fear generalization.Trends in cognitive sciences · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. The hippocampus rapidly integrates sequence representations during novel multistep predictions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Distinct Hippocampal Mechanisms Support Concept Formation and Updating.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  19. Multistep inference across the human lifespan can be improved with individualized memory interventions.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  20. Article

142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Margaret L SchlichtingDepartment of Psychology, The University of Texas at Austin, 1 University Station A8000, Austin, TX 78712, United States ; Center for Learning and Memory, The University of Texas at Austin, 1 University Station C7000, Austin, TX 78712, United States.
Alison R PrestonDepartment of Psychology, The University of Texas at Austin, 1 University Station A8000, Austin, TX 78712, United States ; Center for Learning and Memory, The University of Texas at Austin, 1 University Station C7000, Austin, TX 78712, United States ; Department of Neuroscience, The University of Texas at Austin, 1 University Station C7000, Austin, TX 78712, United States.

Funding

Hippocampal and prefrontal contributions to memory integrationR01MH100121 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI Alison R Preston · 2013 to 2026
$7.3M
NIMH NIH HHS R01 MH100121
6 · The paper itself

Abstract

Everyday behaviors require a high degree of flexibility, in which prior knowledge is applied to inform behavior in new situations. Such flexibility is thought to be supported in part by memory integration, a process whereby related memories become interconnected in the brain through recruitment of overlapping neuronal populations. Recent advances in cognitive and behavioral neuroscience highlight the importance of a hippocampal-medial prefrontal circuit in memory integration. Emerging evidence suggests that abstracted representations in medial prefrontal cortex guide reactivation of related memories during new encoding events, thus promoting hippocampal integration of related experiences. Moreover, recent work indicates that integrated memories are called upon during novel situations to facilitate a host of behaviors, from spatial navigation to imagination.

Identifiers

PMID25750931
PMCPMC4346341

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.