Evidence map›Paper›PMID 25750689›Full record

ArticleJournal of biomedical science and engineering2013

Spatial perturbation with synthetic protein scaffold reveals robustness of asymmetric cell division.

Jiahe Li, Pengcheng Bu, Kai-Yuan Chen, Xiling Shen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical science and engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jiahe LiDepartment of Biomedical Engineering, Cornell University, Ithaca, USA.
Pengcheng BuSchool of Electrical and Computer Engineering, Cornell University, Ithaca, USA.
Kai-Yuan ChenSchool of Electrical and Computer Engineering, Cornell University, Ithaca, USA.
Xiling ShenDepartment of Biomedical Engineering, Cornell University, Ithaca, USA ; School of Electrical and Computer Engineering, Cornell University, Ithaca, USA.
Cornell University · US

Funding

Multi-scale modeling of asymmetric cell divisionR01GM095990 · NIGMS · CORNELL UNIVERSITY · PI SHEN, XILING · 2011 to 2015
$1.5M
NIGMS NIH HHS R01 GM095990
6 · The paper itself

Abstract

Asymmetric cell division is an important mechanism for creating diversity in a cellular population. Stem cells commonly perform asymmetric division to generate both a daughter stem cell for self-renewal and a more differentiated daughter cell to populate the tissue. During asymmetric cell division, protein cell fate determinants asymmetrically localize to the opposite poles of a dividing cell to cause distinct cell fate. However, it remains unclear whether cell fate determination is robust to fluctuations and noise during this spatial allocation process. To answer this question, we engineered

Indexed as

Asymmetric Cell DivisionCaulobacterProtein ScaffoldSynthetic Biology

Identifiers

PMID25750689
PMCPMC4350780
OpenAlexW2014827703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.