ArticleFrontiers in neurology2015
Salicylate-induced hearing loss and gap detection deficits in rats.
Article in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Optimization of the Operant Silent Gap-in-Noise Detection Paradigm in Humans.Journal of integrative neuroscience · 2024Observational
- The Auditory Brainstem Response (ABR) Test, Supplementary to Behavioral Tests for Evaluation of the Salicylate-Induced Tinnitus.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Objective Detection of Tinnitus Based on Electrophysiology.Brain sciences · 2022Review
- Comparison of two behavioral tests for tinnitus assessment in mice.Frontiers in behavioral neuroscience · 2022Article
- Review: Neural Mechanisms of Tinnitus and Hyperacusis in Acute Drug-Induced Ototoxicity.American journal of audiology · 2021Review
- Hearing loss and brain plasticity: the hyperactivity phenomenon.Brain structure & function · 2021Review
- Salicylate-Induced Changes in Hearing Thresholds in Mongolian Gerbils Are Correlated With Tinnitus Frequency but Not With Tinnitus Strength.Frontiers in behavioral neuroscience · 2021Article
- Customizable Recorder of Animal Kinesis (CRoAK): A multi-axis instrumented enclosure for measuring animal movements.HardwareX · 2020Article
- Article
- A Novel Mouse Model of Aminoglycoside-Induced Hyperacusis and Tinnitus.Frontiers in neuroscience · 2020Article
- Testing the Central Gain Model: Loudness Growth Correlates with Central Auditory Gain Enhancement in a Rodent Model of Hyperacusis.Neuroscience · 2019Article
- Aberrant thalamocortical coherence in an animal model of tinnitus.Journal of neurophysiology · 2019Article
- Up-regulation of CaMolecular and cellular biochemistry · 2018Article
- Addressing variability in the acoustic startle reflex for accurate gap detection assessment.Hearing research · 2018Article
- Salicylate-induced hyperacusis in rats: Dose- and frequency-dependent effects.Hearing research · 2017Article
- Reductions in cortical alpha activity, enhancements in neural responses and impaired gap detection caused by sodium salicylate in awake guinea pigs.The European journal of neuroscience · 2017Article
- Improving the Reliability of Tinnitus Screening in Laboratory Animals.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- A New Statistical Approach for the Evaluation of Gap-prepulse Inhibition of the Acoustic Startle Reflex (GPIAS) for Tinnitus Assessment.Frontiers in behavioral neuroscience · 2017Article
- Salicylate-Induced Suppression of Electrically Driven Activity in Brain Slices from the Auditory Cortex of Aging Mice.Frontiers in aging neuroscience · 2017Article
- Effects of long-term salicylate administration on synaptic ultrastructure and metabolic activity in the rat CNS.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
To test the "tinnitus gap-filling" hypothesis in an animal psychoacoustic paradigm, rats were tested using a go/no-go operant gap detection task in which silent intervals of various durations were embedded within a continuous noise. Gap detection thresholds were measured before and after treatment with a dose of sodium salicylate (200 mg/kg) that reliably induces tinnitus in rats. Noise-burst detection thresholds were also measured to document the amount of hearing loss and aid in interpreting the gap detection results. As in the previous human psychophysical experiments, salicylate had little or no effect on gap thresholds measured in broadband noise presented at high-stimulus levels (30-60 dB SPL); gap detection thresholds were always 10 ms or less. Salicylate also did not affect gap thresholds presented in narrowband noise at 60 dB SPL. Therefore, rats treated with a dose of salicylate that reliably induces tinnitus have no difficulty detecting silent gaps as long as the noise in which they are embedded is clearly audible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.