ArticleFrontiers in synaptic neuroscience2015
Properties and molecular identity of NMDA receptors at synaptic and non-synaptic inputs in cerebellar molecular layer interneurons.
Article in Frontiers in synaptic neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 42 citations in OpenAlex.
- Dendritic interaction of timescales in afterdepolarization potentials and nonmonotonic spike-adding.Journal of computational neuroscience · 2026Article
- Cerebellar basket cell filtering of Purkinje cell responses elicited by low frequency parallel fibre transmission.Scientific reports · 2025Article
- Article
- Afferent convergence to a shared population of interneuron AMPA receptors.Nature communications · 2023Article
- Specific Dystrophins Selectively Associate with Inhibitory and Excitatory Synapses of the Mouse Cerebellum and their Loss Alters Expression of P2X7 Purinoceptors and Pro-Inflammatory Mediators.Cellular and molecular neurobiology · 2022Article
- Modified climbing fiber/Purkinje cell synaptic connectivity in the cerebellum of the neonatal phencyclidine model of schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Protective Effect of Memantine on Bergmann Glia and Purkinje Cells Morphology in Optogenetic Model of Neurodegeneration in Mice.International journal of molecular sciences · 2021Article
- Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum.Scientific reports · 2021Article
- Interneuronal NMDA receptors regulate long-term depression and motor learning in the cerebellum.The Journal of physiology · 2019Article
- Loss of Ethanol Inhibition of N-Methyl-D-Aspartate Receptor-Mediated Currents and Plasticity of Cerebellar Synapses in Mice Expressing the GluN1(F639A) Subunit.Alcoholism, clinical and experimental research · 2018Article
- Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Presynaptic GluN2D receptors detect glutamate spillover and regulate cerebellar GABA release.Journal of neurophysiology · 2016Article
- Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity.Trends in neurosciences · 2016Review
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Authors and funding
5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
N-methyl-D-aspartate receptors (NMDARs) in cerebellar molecular layer interneurons (MLIs) are expressed and activated in unusual ways: at parallel fibre (PF) synapses they are only recruited by repetitive stimuli, suggesting an extrasynaptic location, whereas their activation by climbing fibre is purely mediated by spillover. NMDARs are thought to play an important role in plasticity at different levels of the cerebellar circuitry. Evaluation of the location, functional properties and physiological roles of NMDARs will be facilitated by knowledge of the NMDAR isoforms recruited. Here we show that MLI-NMDARs activated by both PF and climbing fibre inputs have similar kinetics and contain GluN2B but not GluN2A subunits. On the other hand, no evidence was found of functional NMDARs in the axons of MLIs. At the PF-Purkinje cell (PF-PC) synapse, the activation of GluN2A-containing NMDARs has been shown to be necessary for the induction of long-term depression (LTD). Our results therefore provide a clear distinction between the NMDARs located on MLIs and those involved in plasticity at PF-PC synapses.
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