ArticleNeuropsychiatric disease and treatment2015
Electroencephalography reveals lower regional blood perfusion and atrophy of the temporoparietal network associated with memory deficits and hippocampal volume reduction in mild cognitive impairment due to Alzheimer's disease.
Article in Neuropsychiatric disease and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Systematic Review on Resting-State EEG for Alzheimer's Disease Diagnosis and Progression Assessment.Disease markers · 2018Pooled it
- Age-dependent electroencephalogram alterations under remimazolam anesthesia.Korean journal of anesthesiology · 2026Observational
- Frontotemporal EEG as potential biomarker for early MCI: a case-control study.BMC psychiatry · 2022Article
- Resting EEG, Hair Cortisol and Cognitive Performance in Healthy Older People with Different Perceived Socioeconomic Status.Brain sciences · 2020Article
- Vascular biomarkers and ApoE4 expression in mild cognitive impairment and Alzheimer's disease.AIMS neuroscience · 2018Article
- Progranulin Mutations Affects Brain Oscillatory Activity in Fronto-Temporal Dementia.Frontiers in aging neuroscience · 2016Article
- Electroencephalography-driven approach to prodromal Alzheimer's disease diagnosis: from biomarker integration to network-level comprehension.Clinical interventions in aging · 2016Article
- Exercise-Related Changes of Networks in Aging and Mild Cognitive Impairment Brain.Frontiers in aging neuroscience · 2016Review
- Mild Cognitive Impairment: Structural, Metabolical, and Neurophysiological Evidence of a Novel EEG Biomarker.Frontiers in neurology · 2015Review
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1 author at 1 institution in 1 country.
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Abstract
backgroundAn increased electroencephalographic (EEG) upper/lower alpha power ratio has been associated with less regional blood perfusion, atrophy of the temporoparietal region of the brain, and reduction of hippocampal volume in subjects affected by mild cognitive impairment due to Alzheimer's disease as compared with subjects who do not develop the disease. Moreover, EEG theta frequency activity is quite different in these groups. This study investigated the correlation between biomarkers and memory performance.
methodsEEG α3/α2 power ratio and cortical thickness were computed in 74 adult subjects with prodromal Alzheimer's disease. Twenty of these subjects also underwent assessment of blood perfusion by single-photon emission computed tomography (SPECT). Pearson's r was used to assess the correlation between cortical thinning, brain perfusion, and memory impairment.
resultsIn the higher α3/α2 frequency power ratio group, greater cortical atrophy and lower regional perfusion in the temporoparietal cortex was correlated with an increase in EEG theta frequency. Memory impairment was more pronounced in the magnetic resonance imaging group and SPECT groups.
conclusionA high EEG upper/low alpha power ratio was associated with cortical thinning and less perfusion in the temporoparietal area. Moreover, atrophy and less regional perfusion were significantly correlated with memory impairment in subjects with prodromal Alzheimer's disease. The EEG upper/lower alpha frequency power ratio could be useful for identifying individuals at risk for progression to Alzheimer's dementia and may be of value in the clinical context.
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