ArticleClinical ophthalmology (Auckland, N.Z.)2015
Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies.
Article in Clinical ophthalmology (Auckland, N.Z.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- An Overview of Rheumatoid Arthritis-Associated Dry Eye Disease, Scleritis, and Peripheral Ulcerative Keratitis.Journal of clinical medicine · 2026Review
- Case Report: Orbital and intracranial inflammatory syndrome in rheumatoid arthritis.Frontiers in ophthalmology · 2026Article
- Felty Syndrome in a Patient Presenting With Bilateral Scleritis and Multiple Autoimmune Syndrome: A Case Report.Cureus · 2024Article
- Clinical implications of seropositive and seronegative autoantibody status in rheumatoid arthritis patients: A comparative multicentre observational study.Rheumatology and immunology research · 2024Article
- Non-contact meibography changes according to disease activity in rheumatoid arthritis cases.BMC ophthalmology · 2023Article
- Hydroxychloroquine is neutral on incidental cataracts in patients with rheumatoid arthritis.Scientific reports · 2023Article
- Ocular disease as the presenting sign of rheumatoid arthritis - An observational case series.Indian journal of ophthalmology · 2023Observational
- Spectrum of and Factors Associated with Eye Disorders among Rheumatoid Arthritis Patients Attending Tertiary Hospital in Uganda.Open access rheumatology : research and reviews · 2023Article
- Scleritis in rheumatoid arthritis: Before and during biologic era.Frontiers in ophthalmology · 2023Article
- Adalimumab plus Conventional Therapy versus Conventional Therapy in Refractory Non-Infectious Scleritis.Journal of clinical medicine · 2022Article
- [Association of the different forms of uveitis with inflammatory rheumatic diseases and their treatment].Zeitschrift fur Rheumatologie · 2022Review
- Red flag: Ocular clues to systemic disease.Indian journal of ophthalmology · 2022Article
- Ocular Manifestations Related to Antibodies Positivity and Inflammatory Biomarkers in a Rheumatological Cohort.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Comparison of Intestinal Microbes in Noninfectious Anterior Scleritis Patients With and Without Rheumatoid Arthritis.Frontiers in microbiology · 2022Article
- Immunopathological Analysis of a Mouse Model of Arthritis-Associated Scleritis and Implications for Molecular Targeted Therapy for Severe Scleritis.International journal of molecular sciences · 2021Article
- Rheumatoid Arthritis Associated Episcleritis and Scleritis: An Update on Treatment Perspectives.Journal of clinical medicine · 2021Review
- Ocular Manifestations in Colombian Patients with Systemic Rheumatologic Diseases.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- The association of choroidal thickness with rheumatoid factor and anti-cyclic citrullinated peptide in rheumatoid arthritis.International ophthalmology · 2020Article
- Ocular manifestations of rheumatic diseases.International ophthalmology · 2020Review
- Rheumatoid factor versus anti - cyclic citrullinated peptide antibody as screening tool for rheumatoid arthritis in an ophthalmic clinic.Indian journal of ophthalmology · 2020Article
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2 authors.
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Abstract
purposeTo study the ocular manifestations of rheumatoid arthritis and to correlate the role of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) with the ocular manifestations.
methodsThree-hundred and ninety-two eyes of the 196 rheumatoid arthritis patients who attended the ophthalmology outpatient department underwent a detailed ocular examination using slit lamp biomicroscopy and ophthalmoscopy. The tear function of all the patients was assessed using Schirmer's test, tear film break-up time and ocular surface staining. The anti-CCP antibody titers for all the rheumatoid arthritis patients were estimated using enzyme-linked immunosorbent assay tests.
resultsSeventy-seven patients (135 eyes, 39%) out of the 196 patients studied had ocular manifestations typical of rheumatoid arthritis. Dry eye was the most common manifestation (28%, 54 patients). Of the patients, 78% was females (60 patients). The mean duration of rheumatoid arthritis in patients with ocular manifestations was 5.4±2.7 years and without ocular manifestations was 2.1±1.6years. Three percent of the patients had episcleritis (six patients). Scleritis was present in 2% of the patients (four patients). Peripheral ulcerative keratitis and sclerosing keratitis was present in 1% of the population each (two patients each). Eighty-five percent (66 patients) had bilateral manifestations 15% (eleven patients) had unilateral manifestations. There was a strong association between the presence of anti-CCP antibodies and ocular manifestations of rheumatoid arthritis which was shown by the statistically significant P-value of <0.0001.
conclusionOcular manifestations are a significant part of the extra-articular manifestation of rheumatoid arthritis. Dry eye was the most common ocular manifestation. There was a statistically significant association between the presence of anti-CCP antibodies specific to rheumatoid arthritis and the ocular manifestations.
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