Evidence map›Paper›PMID 25750310›Full record

ArticleAnticancer research2015

Vitamin D receptor genetic polymorphisms are associated with PSA level, Gleason score and prostate cancer risk in African-American men.

Emmanuel Y Jingwi, Muneer Abbas, Luisel Ricks-Santi, Danyelle Winchester, Desta Beyene, Agnes Day, Tammey J Naab, Olakunle O Kassim, Georgia M Dunston, Robert L Copeland and 1 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Anticancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Current urology · 2022
    Article
  7. Article
  8. Review
  9. Article
  10. Vitamin D receptorOncotarget · 2018
    Article
  11. Article
  12. African-American Prostate Cancer Disparities.Current urology reports · 2017
    Review
  13. Article
  14. Prostate cancer in men of African origin.Nature reviews. Urology · 2016
    Review
  15. Article
  16. Article
  17. DHPLC Elution Patterns ofCancer genomics & proteomics
    Review
  18. The Association of a Novel IdentifiedCancer genomics & proteomics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Emmanuel Y JingwiCancer Center, Howard University, Washington, DC, U.S.A.
Muneer AbbasDepartment of Microbiology, Howard University, Washington, DC, U.S.A. Department of National Human Genome Center, Howard University, Washington, DC, U.S.A.
Luisel Ricks-SantiCancer Research Center, Hampton University, Hampton, VA, U.S.A.
Danyelle WinchesterDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, U.S.A.
Desta BeyeneCancer Center, Howard University, Washington, DC, U.S.A. Department of Biochemistry, Howard University, Washington, DC, U.S.A.
Agnes DayCancer Center, Howard University, Washington, DC, U.S.A.
Tammey J NaabDepartment of Pathology, Howard University, Washington, DC, U.S.A.
Olakunle O KassimDepartment of Microbiology, Howard University, Washington, DC, U.S.A.
Georgia M DunstonDepartment of Microbiology, Howard University, Washington, DC, U.S.A. Department of National Human Genome Center, Howard University, Washington, DC, U.S.A.
Robert L CopelandDepartment of Pharmacology, Howard University, Washington, DC, U.S.A.
Yasmine M KanaanCancer Center, Howard University, Washington, DC, U.S.A. Department of Microbiology, Howard University, Washington, DC, U.S.A. ymkanaan@howard.edu.
Howard University · USHampton University · USJohns Hopkins University · US

Funding

PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
NIMHD NIH HHS G12 MD007597
6 · The paper itself

Abstract

BACKGROUND/

aimSeveral studies have revealed an association between single nucleotide polymorphisms (SNPs) in the VDR gene and prostate cancer (PCa) risk in European and Asian populations. To investigate whether VDR SNPs are associated with PCa risk in African-American (AA) men, nine VDR SNPs were analyzed in a case-control study. MATERIALS AND

methodsMultiple and binary logistic regression models were applied to analyze the clinical and genotypic data.

resultsrs731236 and rs7975232 were significantly associated with PCa risk (p<0.05). In the analysis of clinical phenotypes, rs731236, rs1544410 and rs3782905 were strongly associated with high PSA level (p<0.05), whereas rs1544410 and rs2239185 showed a statistically significant association with high Gleason score (p<0.05). Haplotype analysis revealed several VDR haplotypes associated with PCa risk. Additionally, a trend existed, where as the number of risk alleles increased in the haplotype, the greater was the association with risk (p-trend=0.01).

conclusionThese results suggest that the VDR SNPs may be associated with PCa risk and other clinical phenotypes of PCa in AA men.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAgedBlack or African AmericanCase-Control StudiesHaplotypesHumansMaleMiddle AgedNeoplasm GradingProstate-Specific AntigenProstatic NeoplasmsReceptors, CalcitriolRiskProstate-Specific AntigenReceptors, CalcitriolAfrican-Americanclinical phenotypeprostate cancerSNPvitamin D receptor

Identifiers

PMID25750310
PMCPMC4743656
OpenAlexW2113040026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.