Trial reportJournal of neurovirology2015
The effects of antiretroviral treatment initiation on cognition in HIV-infected individuals with advanced disease in Pune, India.
Trial report in Journal of neurovirology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Meta-Analytic Review of the Effect of Antiretroviral Therapy on Neurocognitive Outcomes in Adults Living with HIV-1 in Low-and Middle-Income Countries.Neuropsychology review · 2022Pooled it
- The Impact of Antiretroviral Therapy on Neurocognitive Outcomes Among People Living with HIV in Low- and Middle-Income Countries (LMICs): A Systematic Review.AIDS and behavior · 2021Pooled it
- Brief Report: Body Mass Index and Cognitive Function Among HIV-1-Infected Individuals in China, India, and Nigeria.Journal of acquired immune deficiency syndromes (1999) · 2019Pooled it
- Antiretroviral Therapy Intensification for Neurocognitive Impairment in Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Trial
- Language and executive function of clinical stage-1 HIV patients in an industrial scenario: Extent and implication.Industrial psychiatry journal · 2023Article
- Neurocognitive Complications of HIV Infection in Low-Income Countries.Current topics in behavioral neurosciences · 2021Article
- Risk Factors of Asymptomatic Neurocognitive Impairment in People Living with HIV in an Indian Cohort.Journal of neurosciences in rural practice · 2020Article
- Cognitive Impairment in Zambians With HIV Infection and Pulmonary Tuberculosis.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques.Journal of virology · 2018Article
- Neurocognitive impairment with hepatitis C and HIV co-infection in Southern Brazil.Journal of neurovirology · 2018Article
- Neurocognitive functioning among HIV-positive adults in southern India.Journal of neurovirology · 2017Article
- HIV-Associated Neurocognitive Disorders: A Global Perspective.Journal of the International Neuropsychological Society : JINS · 2017Review
- Neuropsychological Assessment: Past and Future.Journal of the International Neuropsychological Society : JINS · 2017Review
- Improving Detection of HIV-Associated Cognitive Impairment: Comparison of the International HIV Dementia Scale and a Brief Screening Battery.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections.Journal of virology · 2016Review
- International neurocognitive normative study: neurocognitive comparison data in diverse resource-limited settings: AIDS Clinical Trials Group A5271.Journal of neurovirology · 2016Article
- Automated procedure for demographic adjustments on cognitive test scores.Applied neuropsychology. AdultArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
There has been a reduction in the most severe cases of HIV-associated neurocognitive disorders (HAND) with advances in antiretroviral treatment (ART). But the prevalence of milder forms of HAND still remains high. Data from systematically conducted studies on the effects of ART on cognition are scanty in India, where HIV-1 clade C is prevalent. The purpose of the present study was to assess the effect of antiretroviral therapy in HIV-seropositive (HIV+) individuals (n = 92) with CD4 cell counts <200 cells/mm(3). The overall and domain-specific levels of cognitive functioning were determined using a locally recruited normative sample, and a change in neurocognitive functioning at the 1-year follow-up visit was analyzed. Results revealed cognitive impairment in 44.6 % of the HIV+ group at baseline. At the 1-year follow-up, the group showed significant improvement in the Learning domain (p < 0.05). HIV+ individuals showing improvement in the global cognitive scores had a significantly lower baseline CD4 cell count compared to others. Overall, the degree of improvement associated with the magnitude of rise in CD4 suggests the possibility that early, mild subclinical deficits may also benefit from treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.