Evidence map›Paper›PMID 25749972›Full record

ArticleCancer discovery2015

From histones to ribosomes: a chromatin regulator tangoes with translation.

Scott B Rothbart, Bradley M Dickson, Brian D Strahl

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer discovery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Scott B RothbartCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan. brian_strahl@med.unc.edu scott.rothbart@vai.org.
Bradley M DicksonCenter for Integrative Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Brian D StrahlDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. brian_strahl@med.unc.edu scott.rothbart@vai.org.
University of North Carolina at Chapel Hill · US

Funding

DISCOVERY OF CHEMICAL PROBES FOR METHYL-LYSINE READERSR01GM100919 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRYE, STEPHEN VERNON · 2012 to 2019
$2.9M
Factors that regulate chromatin organization and gene transcriptionR01GM110058 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STRAHL, BRIAN D · 2014 to 2017
$1.2M
Mechanisms Regulating DNA Methylation Maintenance in ChromatinR00CA181343 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI ROTHBART, SCOTT · 2015 to 2017
$746k
Mechanisms Regulating DNA Methylation Maintenance in ChromatinK99CA181343 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROTHBART, SCOTT · 2014 to 2015
$211k
NCI NIH HHS K99 CA181343NCI NIH HHS R00 CA181343NIGMS NIH HHS R01 GM100919NIGMS NIH HHS R01 GM110058
6 · The paper itself

Abstract

Histone lysine methylation is a critical regulator of chromatin-templated processes such as gene transcription and DNA repair, and is dynamically controlled by enzymes that write and erase this posttranslational modification. Although histone methylation has been well studied, the functions of nonhistone lysine methylation and its regulatory enzymes, particularly outside the nucleus, are poorly defined. In this issue of Cancer Discovery, Van Rechem and colleagues shed light on a new role for the lysine demethylase KDM4A as a regulator of protein translation and identify a single-nucleotide polymorphism in the KDM4A gene as a candidate biomarker for mTOR inhibitor therapy.

Indexed as

Open Reading FramesPolymorphism, Single NucleotideProtein BiosynthesisAntineoplastic AgentsDrug Resistance, NeoplasmHumansJumonji Domain-Containing Histone DemethylasesLysineProtein Kinase InhibitorsTOR Serine-Threonine KinasesAntineoplastic AgentsJumonji Domain-Containing Histone DemethylasesKDM4A protein, humanLysineProtein Kinase InhibitorsTOR Serine-Threonine Kinases

Identifiers

PMID25749972
PMCPMC4355909
OpenAlexW1971441586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.