ArticleAllergy, asthma & immunology research2015
Diagnostic Decision Points of Specific IgE Concentrations in Korean Children With Egg and Cow's Milk Allergies.
Article in Allergy, asthma & immunology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Diagnostic Decision Points of Specific Immunoglobulin E Concentrations for Seafood Allergies in Korean Children: A Nationwide Multicenter Study.Allergy, asthma & immunology research · 2025Article
- Assessment of egg and milk allergies among Indians by revalidating a food allergy predictive model.The World Allergy Organization journal · 2022Article
- Infantile Anaphylaxis in Korea: a Multicenter Retrospective Case Study.Journal of Korean medical science · 2019Article
- Prevalence of food-allergen and aeroallergen sensitization among people in Sichuan, Western China: An 8-year observational study.Journal of clinical laboratory analysis · 2019Observational
- Oral food challenges: result of a 16-year experience at a major teaching hospital in Thailand.Asia Pacific allergy · 2018Article
- IgE-mediated food allergies in children: prevalence, triggers, and management.Korean journal of pediatrics · 2017Review
- Article
- Diagnostic Value of Specific IgE to Peanut and Ara h 2 in Korean Children with Peanut Allergy.Allergy, asthma & immunology research · 2016Article
- Diagnostic Decision Points of Specific IgE Titers in Patients With Food Allergy: Are They Appropriate in All Clinical Settings?Allergy, asthma & immunology research · 2015Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to evaluate the utility of specific IgE (sIgE) concentrations for the diagnosis of immediate-type egg and cow's milk (CM) allergies in Korean children and to determine the optimal cutoff levels.
methodsIn this prospective study, children ≥12 months of age with suspected egg or CM allergy were enrolled. Food allergy was diagnosed by an open oral food challenge (OFC) or through the presence of a convincing history after ingestion of egg or CM. The cutoff levels of sIgE for egg white (EW) and CM were determined by analyzing the receiver operating characteristic curves.
resultsOut of 273 children, 52 (19.0%) were confirmed to have egg allergy. CM allergy was found in 52 (23.1%) of 225 children. The EW-sIgE concentration indicating a positive predictive value (PPV) of >90% was 28.1 kU/L in children <24 months of age and 22.9 kU/L in those ≥24 months of age. For CM-sIgE, the concentration of 31.4 kU/L in children <24 months of age and 10.1 kU/L in those ≥24 months of age indicated a >90% PPV. EW-sIgE levels of 3.45 kU/L presented a negative predictive value (NPV) of 93.6% in children <24 months of age, while 1.80 kU/L in those ≥24 months of age presented a NPV of 99.2%. The CM-sIgE levels of 0.59 kU/L in children <24 months of age and 0.94 kU/L in those ≥24 months of age showed NPVs of 100% and 96.9%.
conclusionsOur results indicate that different diagnostic decision points (DDPs) of sIgE levels should be used for the diagnosis of egg or CM allergy in Korean children. The data also suggest that DDPs with high PPV and high NPV are useful for determining whether OFC is required in children with suspected egg or CM allergy.
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