Observational studyLangenbeck's archives of surgery2015
Necessity of therapy for post-thyroidectomy hypocalcaemia: a multi-centre experience.
Observational study in Langenbeck's archives of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Definition and diagnosis of postsurgical hypoparathyroidism after thyroid surgery: meta-analysis.BJS open · 2022Pooled it
- What are the real rates of temporary hypoparathyroidism following thyroidectomy? It is a matter of definition: a systematic review.Endocrine · 2021Pooled it
- Huge variations in definition and reported incidence of postsurgical hypoparathyroidism: a systematic review.Endocrine · 2019Pooled it
- Impact of autofluorescence for detection of parathyroid glands during thyroidectomy on postoperative parathyroid hormone levels: parallel multicentre randomized clinical trial.The British journal of surgery · 2023Trial
- Short-Term Hypocalcemia Prophylaxis With Calcitriol Before Thyroidectomy.Deutsches Arzteblatt international · 2021Trial
- Risk factors of hypocalcemia after total thyroidectomy. A high volume center experience.Frontiers in endocrinology · 2025Article
- Management of surgical diseases of thyroid gland indications of the United Italian Society of Endocrine Surgery (SIUEC).Updates in surgery · 2023Article
- Epidemiology and Financial Burden of Adult Chronic Hypoparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Review
- Can preoperative 25-hydroxyvitamin D levels predict transient hypocalcemia after total thyroidectomy?Updates in surgery · 2022Article
- European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: Recommendations of the ESE Educational Program of Parathyroid Disorders.European journal of endocrinology · 2022Article
- Advanced Differentiated Thyroid Cancer: A Complex Condition Needing a Tailored Approach.Frontiers in oncology · 2022Article
- Etiology and Diagnosis of Permanent Hypoparathyroidism after Total Thyroidectomy.Journal of clinical medicine · 2021Review
- The prevalence of hypocalcemia following total thyroidectomy. A retrospective study based at King Abdulaziz University Hospital, Jeddah, Saudi Arabia.Saudi medical journal · 2020Article
- Can preoperative vitamin D deficiency predict postoperative hypoparathyroidism following thyroid surgery?Langenbeck's archives of surgery · 2019Article
- A proposal for thyroid surgery: criteria to identify the references of endocrine surgery.Updates in surgery · 2017Article
- The PGRIS and parathyroid splinting concepts for the analysis and prognosis of protracted hypoparathyroidism.Gland surgery · 2017Article
- A nomogram to predict the likelihood of permanent hypoparathyroidism after total thyroidectomy based on delayed serum calcium and iPTH measurements.Gland surgery · 2017Article
- Prolonged Duration of Surgery Predicts Postoperative Hypoparathyroidism among Patients Undergoing Total Thyroidectomy in a Tertiary Referral Centre.European thyroid journal · 2017Article
- How to avoid and to manage post-operative complications in thyroid surgery.Updates in surgery · 2017Review
- Diagnostic, therapeutic and health-care management protocol in thyroid surgery: a position statement of the Italian Association of Endocrine Surgery Units (U.E.C. CLUB).Journal of endocrinological investigation · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHypoparathyroidism is one of the most common and most feared complications of total thyroidectomy (TT). The aim of this study is to detect possible markers that may facilitate early tracing of hypocalcaemia-prone patients in order to reduce clinical cost by optimizing patient discharge and to avoid unnecessary treatment.
methodsOver an 18-month period, 995 patients, 23 % male and 77 % female, aged 52.9 ± 13.4 years, underwent TT in ten Lombardy hospitals. The following parameters were analyzed: calcaemia before and 12-24 and 48 h after surgery, pre- and post-operative parathyroid hormone (PTH) at 24 h and pre-operative 25OH vitamin D.
resultsMortality was nil and morbidity was 22.4 %. Mean 24-h calcaemia and PTH were 2.17 ± 0.15 mmol/l and 31.81 ± 20.35 pg/ml, respectively; mean 24-h PTH decay was 36.7 ± 34.12 %. Four hundred seventy-three (47.5 %) patients were hypocalcaemic at discharge; 142 of whom had transient hypoparathyroidism that became permanent in 27. Patients developing hypocalcaemia had significantly higher values of PTH and calcium decay. At multiple logistic regression, only 24-h calcium decay, PTH drop and the presence of symptoms and parathyroid auto-grafting were significantly related to hypoparathyroidism. The association of these factors had a 99.2 % negative predictive value (NPV) for the development of hypoparathyroidism. A 70 % PTH drop had a 93.75 NPV for transient hypoparathyroidism. A 12 % calcaemia decay had a 95.7 NPV for hypoparathyroidism.
conclusionsHypocalcaemic asymptomatic patients with less than 70 % PTH and 12 % calcaemia decay may be safely discharged without treatment. Symptomatic patients and those with parathyroid grafting should receive calcium and vitamin D.
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