ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2015
Differentiation of tuberculosis and metastatic cancer in the spine using dynamic contrast-enhanced MRI.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Classification of spinal tuberculous infection, pyogenic infection and spinal metastasis from magnetic resonance imaging using machine learning.BMC musculoskeletal disorders · 2026Article
- Case report: Tumor-like mediastinal tuberculous lymphadenitis with paravertebral cold abscess under cumulative immunosuppression: a case highlighting altered host-pathogen interactions.Frontiers in immunology · 2026Article
- Multiparametric spinal MRI for differentiating benign and malignant vertebral compression fractures.Radiologie (Heidelberg, Germany) · 2025Article
- A rare case of muscular echinococcosis.Oxford medical case reports · 2025Article
- Article
- Multimodal Magnetic Resonance Imaging and Radiomics in Brucella Spondylitis: Diagnostic Applications and Differential Diagnosis.Journal of multidisciplinary healthcare · 2025Review
- Unmasking the great imitators-noninfectious conditions masquerading as spinal tuberculosis in a developing country: A single-center case series analysis.North American Spine Society journal · 2023Article
- Contrast-enhanced magnetic resonance image segmentation based on improved U-Net and Inception-ResNet in the diagnosis of spinal metastases.Journal of bone oncology · 2023Article
- Diagnosis and Treatment of Skipped Multifocal Spinal Tuberculosis Lesions.Orthopaedic surgery · 2023Review
- Advances in Bone Marrow Imaging: Strengths and Limitations from a Clinical Perspective.Seminars in musculoskeletal radiology · 2023Article
- Early diagnosis of spinal tuberculosis by magnetic resonance: perfusion weighted imaging in a rabbit model.BMC medical imaging · 2022Article
- Imaging update in spinal tuberculosis.Journal of clinical orthopaedics and trauma · 2022Review
- Rapid-kilovoltage-switching dual-energy computed tomography (CT) for differentiating spinal osteolytic metastases from spinal infections.Quantitative imaging in medicine and surgery · 2021Article
- Development and Validation of a Scoring System for Differential Diagnosis of Tuberculosis and Metastatic Tumor in the Spine.Infection and drug resistance · 2021Article
- [CT spectral curve in differentiating spinal tumor metastasis and infections].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- Use of monoexponential diffusion-weighted imaging and diffusion kurtosis imaging and dynamic contrast-enhanced-MRI for the differentiation of spinal tumors.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020Article
- Evaluate the characteristics and clinical significance of "toxic twin-leaf" sign in spinal epidural metastases before percutaneous vertebroplasty.Journal of interventional medicine · 2020Article
- Diagnosis of spinal lesions using perfusion parameters measured by DCE-MRI and metabolism parameters measured by PET/CT.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020Article
- Differentiation of spinal metastases originated from lung and other cancers using radiomics and deep learning based on DCE-MRI.Magnetic resonance imaging · 2019Article
- Imaging of the spine: Where do we stand?World journal of radiology · 2019Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo investigate the differences between imaging features of spinal tuberculosis (TB) and metastatic cancer measured by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The presentation of TB on convention MRI may not show the typical TB signs, and they may be mis-diagnosed as malignant diseases. DCE-MRI may provide additional information to help making differential diagnosis. MATERIALS AND
methodsDCE-MRI was performed in 24 TB and 22 metastatic cancer patients. The DCE kinetic pattern was determined as "wash-out", "plateau" or "persistent enhancement". The characteristic DCE parameters were calculated from the signal intensity time course. The two-compartmental pharmacokinetic model was used to obtain K (trans), which is the parameter associated with the delivery of MR contrast agents into the lesion, and k ep, which is the parameter associated with the distribution and clearance of contrast agents from the lesion.
resultsOf the 24 TB, one case showed the wash-out kinetic pattern, 12 cases showed the plateau pattern, and 11 cases showed the persistent enhancement pattern. Of the 22 metastatic cancers, 12 cases showed wash-out, 7 cases showed plateau, and 3 cases showed persistent enhancement patterns. Compared to the metastatic cancer group, the TB group had a lower k ep (0.27 ± 0.15 vs. 0.49 ± 0.23 min(-1), P < 0.001). The ROC analysis showed that the area under the curve was 0.780 for k ep.
conclusionsDCE-MRI may provide additional information for differentiation between spinal TB and metastasis, when their manifestations on conventional imaging were similar.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.