ReviewCurrent hypertension reports2015
Thiazide Diuretics in Chronic Kidney Disease.
Review in Current hypertension reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease.The New England journal of medicine · 2021Trial
- A Randomized Trial of Distal Diuretics versus Dietary Sodium Restriction for Hypertension in Chronic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2020Trial
- Druggability Studies of Benzene Sulfonamide Substituted Diarylamide (E3) as a Novel Diuretic.Biomedicines · 2025Article
- Structural bases for NaNature communications · 2024Article
- Deep lymph node enlargement and renal failure caused by hypercalcemia‑associated sarcoidosis: A case report.Experimental and therapeutic medicine · 2024Article
- Transcatheter arterial chemoembolization of apatinib and camrelizumab (SHR1210) against liver metastasis from hepatic neuroendocrine tumor: a case report.Frontiers in oncology · 2024Article
- [Chlorthalidone in chronic kidney disease].Innere Medizin (Heidelberg, Germany) · 2023Article
- Structure of the human cation-chloride cotransport KCC1 in an outward-open state.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hydrochlorothiazide: A savior to the heart or a foe to the skin?Annals of medicine and surgery (2012) · 2022Article
- Potentially Inappropriate Medication and Associated Factors Among Older Patients with Chronic Coronary Syndrome at Hospital Discharge in Beijing, China.Clinical interventions in aging · 2021Article
- Fibroblast growth factor 23 and tubular sodium handling in young patients with incipient chronic kidney disease.Clinical kidney journal · 2020Article
- Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy.Nature communications · 2020Article
- Design and Baseline Characteristics of the Chlorthalidone in Chronic Kidney Disease (CLICK) Trial.American journal of nephrology · 2020Article
- KDOQI US Commentary on the 2017 ACC/AHA Hypertension Guideline.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Review
- Antihypertensive therapy prescribing patterns and correlates of blood pressure control among hypertensive patients with chronic kidney disease.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Renoprotection Provided by Additional Diuretic Treatment in Partially Nephrectomized Ren-2 Transgenic Rats Subjected to the Combined RAS and ETFrontiers in physiology · 2019Article
- Treatment of Disorders of Sodium Balance in Chronic Kidney Disease.Advances in chronic kidney disease · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Widely prevalent in the general population, chronic kidney disease (CKD) is frequently complicated with hypertension. Control of hypertension in this high-risk population is a major modifiable cardiovascular and renal risk factor but often requires multiple medications. Although thiazides are an attractive agent, guidelines have previously recommended against thiazide use in stage 4 CKD. We review the updated guidelines on thiazide use in advanced CKD, the antihypertensive mechanism of thiazides, and the clinical studies of thiazides in CKD. Older uncontrolled studies have shown that metolazone reduces blood pressure in CKD, but more recently small randomized controlled trials of hydrochlorothiazide in CKD have shown significant improvement in mean arterial pressure of 15 mmHg. Two recent uncontrolled studies of chlorthalidone including one that used ambulatory blood pressure monitoring found significant improvements in blood pressure. These findings all suggest that thiazides may be efficacious even in advanced CKD; however, electrolyte abnormalities were common in the studies reviewed so close monitoring is necessary during use. Adequately powered randomized trials are now needed before the routine use of thiazide diuretics in advanced CKD can be recommended.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.