ArticlePloS one2015
Intermittent fasting results in tissue-specific changes in bioenergetics and redox state.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 82 citations in OpenAlex.
- Nutrition as Modulator of Oxidative Stress in Cancer Prevention and Treatment.International journal of molecular sciences · 2026Review
- The role of intermittent fasting in modulating oxidative stress: a narrative review.Molecular biology reports · 2026Review
- Impact of Intermittent Fasting on Survival and Gene Expression Profiles Associated with Autophagy, Metabolism, and Antioxidant inACS omega · 2025Article
- Nutritional strategies cause memory damage and alter biochemical parameters without causing neuroinflammation.Metabolic brain disease · 2024Article
- Time-restricted feeding combined with resistance exercise prevents obesity and improves lipid metabolism in the liver of mice fed a high-fat diet.American journal of physiology. Endocrinology and metabolism · 2023Article
- Exploring the precision redox map during fasting-refeeding and satiation in C. elegans.Stress biology · 2023Article
- Beneficial effects of intermittent fasting: a narrative review.Journal of Yeungnam medical science · 2023Article
- Review
- Article
- The Effect of Fasting on Oxidative Stress in the Vital Organs of New Zealand White Rabbit.Reports of biochemistry & molecular biology · 2022Article
- Intermittent fasting induces chronic changes in the hepatic gene expression of Red Jungle Fowl (Gallus gallus).BMC genomics · 2022Article
- Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting.Molecular metabolism · 2020Article
- Intermittent Fasting Attenuates Exercise Training-Induced Cardiac Remodeling.Arquivos brasileiros de cardiologia · 2020Article
- Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats.Nutrients · 2020Article
- Dietary Restriction and Epigenetics: Part I.Conditioning medicine · 2019Article
- Every-Other-Day Feeding Decreases Glycolytic and Mitochondrial Energy-Producing Potentials in the Brain and Liver of Young Mice.Frontiers in physiology · 2019Article
- Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet.Frontiers in physiology · 2019Review
- Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost.Functional ecology · 2018Article
- Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence.Nature reviews. Cardiology · 2018Review
- Intermittent Fasting: Is the Wait Worth the Weight?Current obesity reports · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intermittent fasting (IF) is a dietary intervention often used as an alternative to caloric restriction (CR) and characterized by 24 hour cycles alternating ad libitum feeding and fasting. Although the consequences of CR are well studied, the effects of IF on redox status are not. Here, we address the effects of IF on redox state markers in different tissues in order to uncover how changes in feeding frequency alter redox balance in rats. IF rats displayed lower body mass due to decreased energy conversion efficiency. Livers in IF rats presented increased mitochondrial respiratory capacity and enhanced levels of protein carbonyls. Surprisingly, IF animals also presented an increase in oxidative damage in the brain that was not related to changes in mitochondrial bioenergetics. Conversely, IF promoted a substantial protection against oxidative damage in the heart. No difference in mitochondrial bioenergetics or redox homeostasis was observed in skeletal muscles of IF animals. Overall, IF affects redox balance in a tissue-specific manner, leading to redox imbalance in the liver and brain and protection against oxidative damage in the heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.