Evidence map›Paper›PMID 25749450›Full record

ReviewNature reviews. Microbiology2015

Salmonellae interactions with host processes.

Doris L LaRock, Anu Chaudhary, Samuel I Miller

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 262 papers.

0numbers the graph read from it
0cells of the map it votes in
262citing papers in PubMed
61.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

262 citing papers in PubMed, 485 citations in OpenAlex.

  1. Article
  2. Article
  3. Internalization ofAnnals of medicine · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Host prenylation promotes membrane association of theMicrobiology (Reading, England) · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. bioRxiv : the preprint server for biology · 2026
    Article
  19. Article
  20. Infection strategies ofGut microbes reports · 2026
    Review

202 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Doris L LaRockDepartment of Microbiology, University of Washington, Seattle, Washington 98195, USA.
Anu ChaudharyDepartment of Microbiology, University of Washington, Seattle, Washington 98195, USA.
Samuel I Miller1] Department of Microbiology, University of Washington, Seattle, Washington 98195, USA. [2] Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA. [3] Department of Immunology, University of Washington, Seattle, Washington 98195, USA. [4] Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
University of Washington · US

Funding

ZDS2P REGULATES SWE1P-DEPENDENT POLARIZED CELL GROWTH IN S CEREVISIAEP41RR011823 · NCRR · UNIVERSITY OF WASHINGTON · PI DAVIS, TRACY · 1996 to 2011
$24.7M
Prevalence and Correlates of NTS Bacteremia, Diarrhea and Carriage in KenyaU19AI090882 · NIAID · UNIVERSITY OF WASHINGTON · PI KEMNER, JOHN M · 2010 to 2014
$5.6M
ROLE OF THE PHOP REGULON IN SALMONELLA VIRULENCER01AI030479 · NIAID · UNIVERSITY OF WASHINGTON · PI MILLER, SAMUEL I · 1991 to 2014
$5.3M
SALMONELLA PATHOGENICITY ISLAND 2 EFFECTOR PROTEINSR01AI048683 · NIAID · UNIVERSITY OF WASHINGTON · PI MILLER, SAMUEL I · 2001 to 2015
$5.1M
NCRR NIH HHS P41 RR011823NIAID NIH HHS R01 AI030479NIAID NIH HHS R01 AI048683NIAID NIH HHS U19 AI090882
6 · The paper itself

Abstract

Salmonellae invasion and intracellular replication within host cells result in a range of diseases, including gastroenteritis, bacteraemia, enteric fever and focal infections. In recent years, considerable progress has been made in our understanding of the molecular mechanisms that salmonellae use to alter host cell physiology; through the delivery of effector proteins with specific activities and through the modulation of defence and stress response pathways. In this Review, we summarize our current knowledge of the complex interplay between bacterial and host factors that leads to inflammation, disease and, in most cases, control of the infection by its animal hosts, with a particular focus on Salmonella enterica subsp. enterica serovar Typhimurium. We also highlight gaps in our knowledge of the contributions of salmonellae and the host to disease pathogenesis, and we suggest future avenues for further study.

Indexed as

Host-Pathogen InteractionsAnimalsEpithelial CellsHumansInflammationSalmonella InfectionsSalmonella typhimuriumStress, Physiological

Identifiers

PMID25749450
PMCPMC5074537
OpenAlexW2021024902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.