ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Exercise training-induced bradycardia: evidence for enhanced parasympathetic regulation without changes in intrinsic sinoatrial node function.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Dual Nature of Sinoatrial Node Remodelling in Athletes: A Systematic Review of Electrophysiological Adaptations and the Pathological Tipping Point.International journal of molecular sciences · 2025Pooled it
- Aerobic Endurance Training Modulates Cardiac Renin-Angiotensin System Peptides and Matrix Metalloproteinase Activity During Chronic Stress.Journal of cellular and molecular medicine · 2026Article
- The interaction between exercise and sleep with heart rate variability: cross-sectional study.European journal of applied physiology · 2026Article
- The association between domain-specific physical activity in adults and Parkinson's disease and all-cause mortality: a NHANES study from 2007 to 2018.Biology of sport · 2026Article
- II - Evaluation of Autonomic Control of Heart Rate in Various Clinical Conditions.Arquivos brasileiros de cardiologia · 2025Review
- Dysfunction in Cardiovascular Autonomic Modulation Caused by Chronic Use of Ketamine Hydrochloride Can Be Prevented by Aerobic Exercise Training in Wistar Rats.Journal of clinical medicine · 2025Article
- Protecting the Heart in Motion: The Role of Physical Activity and Cardiorespiratory Fitness in Preventing Sudden Cardiac Death.Clinical Medicine Insights. Cardiology · 2025Review
- The new perspective of cardiac exercise rehabilitation: based on integrative physiology.Frontiers in physiology · 2025Review
- Maximal Resistance Training in the Treatment of Anorexia Nervosa - A Case Report Series.International journal of exercise science · 2024Article
- Article
- Exercise preconditioning improves electrocardiographic signs of myocardial ischemic/hypoxic injury and malignant arrhythmias occurring after exhaustive exercise in rats.Scientific reports · 2022Article
- Psychophysiological and Psychosocial Profile of Patients Attending Drug Addiction Centers.Applied psychophysiology and biofeedback · 2022Article
- Voluntary Exercise Prevents Hypertensive Response Sensitization Induced by Angiotensin II.Frontiers in neuroscience · 2022Article
- Efficacy of high-intensity interval training compared with moderate-intensity continuous training on maximal aerobic potency in dogs: Trial protocol for a randomised controlled clinical study.Veterinary record open · 2021Article
- Aerobic fitness is inversely associated with neurohemodynamic transduction and blood pressure variability in older adults.GeroScience · 2021Article
- Contraction-relaxation coupling is unaltered by exercise training and infarction in isolated canine myocardium.The Journal of general physiology · 2021Article
- Capsiate Intake with Exercise Training Additively Reduces Fat Deposition in Mice on a High-Fat Diet, but Not without Exercise Training.International journal of molecular sciences · 2021Article
- Dissecting the Roles of the Autonomic Nervous System and Physical Activity on Circadian Heart Rate Fluctuations in Mice.Frontiers in physiology · 2021Article
- Opening the Schrödinger Box: Short- and Long-Range Mammalian Heart Rate Variability.Frontiers in physiology · 2021Article
- Advances in understanding mechanisms and therapeutic targets to treat comorbid depression and cardiovascular disease.Neuroscience and biobehavioral reviews · 2020Review
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Abstract
The mechanisms responsible for exercise-induced reductions in baseline heart rate (HR), known as training bradycardia, remain controversial. Therefore, changes in cardiac autonomic regulation and intrinsic sinoatrial nodal (SAN) rate were evaluated using dogs randomly assigned to either a 10- to 12-wk exercise training (Ex, n = 15) or an equivalent sedentary period (Sed, n = 10). Intrinsic HR was revealed by combined autonomic nervous system (ANS) blockade (propranolol + atropine, iv) before and after completion of the study. At the end of the study, SAN function was further evaluated by examining the SAN recovery time (SNRT) following rapid atrial pacing and the response to adenosine in anesthetized animals. As expected, both the response to submaximal exercise and baseline HR significantly (P < 0.01) decreased, and heart rate variability (HRV; e.g., high-frequency R-R interval variability) significantly (P < 0.01) increased in the Ex group but did not change in the Sed group. Atropine also induced significantly (P < 0.01) greater reductions in HRV in the Ex group compared with the Sed group; propranolol elicited similar HR and HRV changes in both groups. In contrast, neither intrinsic HR (Ex before, 141.2 ± 6.7; Ex after, 146.0 ± 8.0 vs. Sed before, 143.3 ± 11.1; Sed after, 141.0 ± 11.3 beats per minute), the response to adenosine, corrected SNRT, nor atrial fibrosis and atrial fibrillation inducibility differed in the Ex group vs. the Sed group. These data suggest that in a large-animal model, training bradycardia results from an enhanced cardiac parasympathetic regulation and not from changes in intrinsic properties of the SAN.
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